{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:00:31Z","timestamp":1785160831869,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["WCU-002-HR-57"],"award-info":[{"award-number":["WCU-002-HR-57"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","award":["WCU-002-HR-57"],"award-info":[{"award-number":["WCU-002-HR-57"]}],"id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2018]]},"abstract":"\n The\n HLA-B<\/jats:italic>\n \n \u2217<\/mml:mo>\n <\/mml:math>\n 15:02<\/jats:italic>\n allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome\/toxic epidermal necrolysis (SJS\/TEN) in Thai patients. The\n \n HLA\n -<\/jats:bold>\n B\n <\/jats:italic>\n alleles associated with carbamazepine-induced maculopapular exanthema (MPE) and the drug reaction with eosinophilia and systemic symptoms (DRESS) among the Thai population have never been reported. The aim of the present study was to carry out an analysis of the involvement of\n HLA-B<\/jats:italic>\n alleles in carbamazepine-induced cutaneous adverse drug reactions (cADRs) in the Thai population. A case-control study was performed by genotyping the\n HLA-B<\/jats:italic>\n alleles of Thai carbamazepine-induced hypersensitivity reaction patients (17 MPE, 16 SJS\/TEN, and 5 DRESS) and 271 carbamazepine-tolerant controls. We also recruited 470 healthy Thai candidate subjects who had not taken carbamazepine.\n HLA-B<\/jats:italic>\n \n \u2217<\/mml:mo>\n <\/mml:math>\n 15:02<\/jats:italic>\n showed a significant association with carbamazepine-induced MPE (\n \n P<\/mml:mi>\n =<\/mml:mo>\n 0.0022<\/mml:mn>\n <\/mml:math>\n , odds ratio (OR) (95% confidence interval [CI])\u2009=\u20097.27 (2.04\u201325.97)) and carbamazepine-induced SJS\/TEN (\n \n P<\/mml:mi>\n =<\/mml:mo>\n 4.46<\/mml:mn>\n \u00d7<\/mml:mo>\n \n \n 10<\/mml:mn>\n <\/mml:mrow>\n \n \u2212<\/mml:mo>\n 13<\/mml:mn>\n <\/mml:mrow>\n <\/mml:msup>\n <\/mml:math>\n ; OR (95% CI)\u2009=\u200970.91(19.67\u2013255.65)) when compared with carbamazepine-tolerant controls. Carbamazepine-induced SJS\/TEN also showed an association with\n HLA-B<\/jats:italic>\n \n \u2217<\/mml:mo>\n <\/mml:math>\n 15:21<\/jats:italic>\n allele (\n \n P<\/mml:mi>\n =<\/mml:mo>\n 0.013<\/mml:mn>\n <\/mml:math>\n ; OR (95% CI)\u2009=\u20099.54 (1.61\u201356.57)) when compared with carbamazepine-tolerant controls.\n HLA-B<\/jats:italic>\n \n \u2217<\/mml:mo>\n <\/mml:math>\n 58:01<\/jats:italic>\n allele was significantly related to carbamazepine-induced MPE (\n \n P<\/mml:mi>\n =<\/mml:mo>\n 0.007<\/mml:mn>\n <\/mml:math>\n ; OR (95% CI)\u2009=\u20094.73 (1.53\u201314.66)) and DRESS (\n \n P<\/mml:mi>\n =<\/mml:mo>\n 0.0315<\/mml:mn>\n <\/mml:math>\n ; OR (95% CI)\u2009=\u20097.55 (1.20\u201347.58)) when compared with carbamazepine-tolerant controls. These alleles may serve as markers to predict carbamazepine-induced cADRs in the Thai population.\n <\/jats:p>","DOI":"10.1155\/2018\/2780272","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T18:33:26Z","timestamp":1515609206000},"page":"1-11","source":"Crossref","is-referenced-by-count":68,"title":["Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0033-5321","authenticated-orcid":true,"given":"Chonlaphat","family":"Sukasem","sequence":"first","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital, Bangkok, Thailand"},{"name":"Ramathibodi Multidisciplinary Epilepsy Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"},{"name":"The Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonlawat","family":"Chaichan","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thapanat","family":"Nakkrut","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand"},{"name":"Department of Pharmacy, Prasat Neurological Institute, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patompong","family":"Satapornpong","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanoot","family":"Jaruthamsophon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkla, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thawinee","family":"Jantararoungtong","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Napatrupron","family":"Koomdee","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suthida","family":"Sririttha","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital, Bangkok, Thailand"},{"name":"Department of Clinical Pharmacy Practice, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadeep","family":"Medhasi","sequence":"additional","affiliation":[{"name":"School of Medicine, Mae Fah Luang University, Chiang Rai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarawut","family":"Oo-Puthinan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ticha","family":"Rerkpattanapipat","sequence":"additional","affiliation":[{"name":"The Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group, Bangkok, Thailand"},{"name":"Division of Allergy Immunology and Rheumatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jettanong","family":"Klaewsongkram","sequence":"additional","affiliation":[{"name":"The Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group, Bangkok, Thailand"},{"name":"Division of Allergy and Clinical Immunology, Skin and Allergy Research Unit, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawinee","family":"Rerknimitr","sequence":"additional","affiliation":[{"name":"The Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group, Bangkok, Thailand"},{"name":"Division of Dermatology, Skin and Allergy Research Unit, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papapit","family":"Tuchinda","sequence":"additional","affiliation":[{"name":"The Thai Severe Cutaneous Adverse 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Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apichaya","family":"Puangpetch","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-510X","authenticated-orcid":true,"given":"Wichai","family":"Aekplakorn","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, 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