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Conventional therapies are always not ideal; development of novel drugs is still needed to achieve better pain relief. Recent evidences have demonstrated that inflammation is involved in the onset and maintenance of DPNP. The anti\u2010inflammatory property of Tanshinone IIA (TIIA) makes it a promising candidate to block or alter the pain perception. This study was conducted to investigate whether TIIA could attenuate DPNP in streptozotocin\u2010 (STZ\u2010) induced rats model and its potential mechanisms. TIIA was administered to STZ\u2010induced diabetic rats at the dose of 40\u2009mg\/kg once a day for 3 weeks. The effects of TIIA on thermal hyperalgesia and mechanical allodynia were investigated using behavioral tests. The mRNA level and expression of interleukin\u2010 (IL\u2010) 1<jats:italic>\u03b2<\/jats:italic>, interleukin\u2010 (IL\u2010) 6, tumor necrosis factor\u2010 (TNF\u2010) <jats:italic>\u03b1<\/jats:italic>, and interleukin\u2010 (IL\u2010) 10 in the fourth to sixth segments of the dorsal root ganglion (L4\u20136 DRG) were detected by quantitative real\u2010time PCR (qPCR) and Western blot. TIIA treatment significantly attenuated mechanical allodynia and thermal hyperalgesia in diabetic rats. In addition, the expression of the proinflammatory cytokines IL\u20101<jats:italic>\u03b2<\/jats:italic>, IL\u20106, and TNF\u2010<jats:italic>\u03b1<\/jats:italic> was inhibited, and the level of the anti\u2010inflammatory cytokine IL\u201010 was increased by TIIA. This study demonstrated that TIIA has significant antiallodynic and antihyperalgesic effects in a rat model of STZ\u2010induced DPNP, and the effect may be associated with its anti\u2010inflammation property.<\/jats:p>","DOI":"10.1155\/2018\/2789847","type":"journal-article","created":{"date-parts":[[2018,3,11]],"date-time":"2018-03-11T23:31:24Z","timestamp":1520811084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Tanshinone IIA Attenuates Diabetic Peripheral Neuropathic Pain in Experimental Rats via Inhibiting 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