{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:43:25Z","timestamp":1740170605199,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,10,21]],"date-time":"2018-10-21T00:00:00Z","timestamp":1540080000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2014Y2-00072","2013B021800198","2017A020215026","A2017314"],"award-info":[{"award-number":["2014Y2-00072","2013B021800198","2017A020215026","A2017314"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"publisher","award":["2014Y2-00072","2013B021800198","2017A020215026","A2017314"],"award-info":[{"award-number":["2014Y2-00072","2013B021800198","2017A020215026","A2017314"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"publisher","award":["2014Y2-00072","2013B021800198","2017A020215026","A2017314"],"award-info":[{"award-number":["2014Y2-00072","2013B021800198","2017A020215026","A2017314"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["2014Y2-00072","2013B021800198","2017A020215026","A2017314"],"award-info":[{"award-number":["2014Y2-00072","2013B021800198","2017A020215026","A2017314"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2018,10,21]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. Basal insulin plus oral hypoglycemic agents (OHAs) has not been investigated for early intensive antihyperglycemic treatment in people with newly diagnosed type 2 diabetes. This study is aimed at comparing the short-term (over a period of 12 days) effects of basal insulin glargine plus OHAs and continuous subcutaneous insulin infusion (CSII) on glycemic control and beta-cell function in this setting. <jats:italic>Methods<\/jats:italic>. An open-label parallel-group study. Newly diagnosed hospitalized patients with type 2 diabetes and fasting plasma glucose (FPG) \u226511.1\u2009mmol\/L or glycated hemoglobin (HbA1c) \u22659% (75\u2009mmol\/mol) were randomized to CSII or insulin glargine in combination with metformin and gliclazide. The primary outcome measure was the mean amplitude of glycemic excursions (MAGE), and secondary endpoints included time to reach glycemic control target (FPG\u2009&lt;\u20097\u2009mmol\/L and 2-hour postprandial plasma glucose\u2009&lt;\u200910\u2009mmol\/L), markers of <jats:italic>\u03b2<\/jats:italic>-cell function, and hypoglycemia. <jats:italic>Results<\/jats:italic>. Subjects in the CSII (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>35<\/mml:mn><\/mml:math>) and basal insulin plus OHA (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>33<\/mml:mn><\/mml:math>) groups had a similar significant reduction from baseline to end of treatment in glycated albumin (\u22126.44\u2009\u00b1\u20093.23% and\u2212\u20096.42\u2009\u00b1\u20093.56%, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.970<\/mml:mn><\/mml:math>). Groups A and B have comparable time to glycemic control (3.6\u2009\u00b1\u20091.2 days and 4.0\u2009\u00b1\u20091.4 days), MAGE (3.40\u2009\u00b1\u20091.40\u2009mmol\/L vs. 3.16\u2009\u00b1\u20091.38\u2009mmol\/L; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.484<\/mml:mn><\/mml:math>), and 24-hour mean blood glucose (7.49\u2009\u00b1\u20090.96\u2009mmol\/L vs. 7.02\u2009\u00b1\u20091.03\u2009mmol\/L). Changes in the C-peptide reactivity index, the secretory unit of islet in transplantation index, and insulin secretion-sensitivity index-2 indicated a greater <jats:italic>\u03b2<\/jats:italic>-cell function improvement with basal insulin plus OHAs versus CSII. <jats:italic>Conclusions<\/jats:italic>. Short-term insulin glargine plus OHAs may be an alternative to CSII for initial intensive therapy in people with newly diagnosed type 2 diabetes.<\/jats:p>","DOI":"10.1155\/2018\/2791584","type":"journal-article","created":{"date-parts":[[2018,10,21]],"date-time":"2018-10-21T19:31:01Z","timestamp":1540150261000},"page":"1-9","source":"Crossref","is-referenced-by-count":1,"title":["A Randomized Trial of Insulin Glargine plus Oral Hypoglycemic Agents versus Continuous Subcutaneous Insulin Infusion to Treat Newly Diagnosed Type 2 Diabetes"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-5864","authenticated-orcid":true,"given":"Shuo","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Lu, Guangzhou 510630, 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