{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:29:39Z","timestamp":1740169779445,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,12,6]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. To evaluate the safety and effectiveness of the injectable bulking agent Opsys\u00ae (Promedon, Cordoba, Argentina) for treating minimal postprostatectomy stress urinary incontinence (SUI).<jats:italic> Patients and Methods<\/jats:italic>. Single-centre, pilot study on ten male patients with SUI, &lt; 30 g urine loss\/ 24 h, more than 1 year after radical prostatectomy. Patients were treated by endoscopic transurethral injections of bulking agent in the presphincteric zone of the urethral submucosa. The results were evaluated using a pad weight test to quantify the differences in urine loss at 1, 3, and 6 months after intervention. Subsequently, the results of treatment were also evaluated by International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF), Incontinence Impact Questionnaire (IIQ-7), Urogenital Distress Inventory Short Form (UDI-6-SF), and the Patient Global Impression of Improvement (PGI-I) at 1, 3, and 6 months after intervention.<jats:italic> Results<\/jats:italic>. The primary outcome was the absolute result of the 24-hour pad weight test after treatment. Treatment success was defined as &lt;3 g urine loss\/24 h, improvement as \u226550% decrease in urine loss\/ 24h, failure as &lt;50% decrease in urine loss\/24 h, or worsening of urine loss. Success was demonstrated in one, improvement in one, and failure in eight patients one month after treatment. One patient improved and 9 failed 3 and 6 months after treatment. The median 24-hour pad weight test was higher at all three moments of follow-up (1, 3, and 6 months after treatment). The median 24-hour pad weight test was before treatment 17.3g (6.4-20.9) and 1, 3, and 6 months after treatment, respectively, 40.3g (5.9-130.6) p= 0.038, 38.3g (18.3-202.1) p= 0.014, 55.0g (16.5-314.6) p= 0.028. The ICIQ-SF was significantly higher at 3 and 6 months, respectively 15.0 (12.0-18.5) p= 0.007 and 16.0 (12.5-17.5) p=0.012 versus 10.0 (9.0-12.0) before injection. No significant differences were found between IIQ-7, UDI-6-SF, and PGI-I before and after injection. Complications occurred in four patients: two patients reported spontaneously resolved haematuria and two patients reported urinary frequency. All complications were classified as Clavien\u2013Dindo 1.<jats:italic> Conclusion<\/jats:italic>. Injection therapy with Opsys\u00ae bulking agent is not an effective treatment option for male SUI after radical prostatectomy. It is not a safe treatment option, due to worsening urine loss after treatment.<\/jats:p>","DOI":"10.1155\/2018\/2796967","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T18:34:29Z","timestamp":1544121269000},"page":"1-6","source":"Crossref","is-referenced-by-count":5,"title":["Injectable Bulking Agent to Treat Postprostatectomy Urinary Incontinence: A Safety and Effectiveness Pilot Study"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0589-3229","authenticated-orcid":true,"given":"Janneke I. M.","family":"van Uhm","sequence":"first","affiliation":[{"name":"Department of Urology, Leiden University Medical Center, 2 Albinusdreef, P.O. Box 9600, Leiden 2300 RC, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marloes","family":"Vermeer","sequence":"additional","affiliation":[{"name":"Ziekenhuisgroep Twente, 141 Geerdinksweg, P.O. Box 546, Hengelo 7550 AM, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk W.","family":"Elzevier","sequence":"additional","affiliation":[{"name":"Department of Urology, Leiden University Medical Center, 2 Albinusdreef, P.O. Box 9600, Leiden 2300 RC, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joop W.","family":"Noordzij","sequence":"additional","affiliation":[{"name":"Amstelland Ziekenhuis, 8 Laan van de Helende Meesters, P.O. Box 328, Amstelveen 1180 AH, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evert L.","family":"Koldewijn","sequence":"additional","affiliation":[{"name":"Catharina Ziekenhuis, 2 Michelangelolaan, P.O. Box 1350, Eindhoven 5602 ZA, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik B.","family":"Cornel","sequence":"additional","affiliation":[{"name":"Ziekenhuisgroep Twente, 141 Geerdinksweg, P.O. Box 546, Hengelo 7550 AM, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"year":"2017","key":"1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.11.034"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.04.019"},{"key":"4","first-page":"CD003881","volume":"2","year":"2012","journal-title":"Cochrane Database of Systematic Reviews (Online)"},{"issue":"3","key":"5","first-page":"92","volume":"31","year":"2012","journal-title":"Pelviperineology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.04.033"},{"issue":"2","key":"7","first-page":"263","volume":"61","year":"2008","journal-title":"Archivos Espa\u00f1oles de Urolog\u00eda"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22683"},{"journal-title":"European Urology Focus","year":"2017","key":"9"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.09.031"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00093-9"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2014.55.3.182"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2004.08.019"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/2796967.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/2796967.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/2796967.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T18:34:31Z","timestamp":1544121271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/2796967\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,6]]},"references-count":13,"alternative-id":["2796967","2796967"],"URL":"https:\/\/doi.org\/10.1155\/2018\/2796967","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2018,12,6]]}}}