{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T21:20:00Z","timestamp":1782768000424,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T00:00:00Z","timestamp":1535932800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,9,3]]},"abstract":"<jats:p><jats:italic>Background and Objectives<\/jats:italic>. Fibroids are related to infertility. Fibroid pseudocapsule is a neurovascular bundle surrounding leiomyomas rich of neurofibers involved in myometrial biology. Authors evaluated, by a case-control study, the fibroid pseudocapsule (FP) thickness by ultrasound (US) and the histological measurements, according to uterine location of fibroids.<jats:italic> Methods<\/jats:italic>. 137 consecutive patients undergoing hysterectomy for uterine myomas were enrolled and 200 myomas were evaluated. Before surgery, patients underwent an ultrasound (US) investigation to evaluate the number, the size, and the location of fibroids. After surgery, myoma-pseudocapsule-myometrium specimens were measured and evaluated by a single expert pathologist. Both US and histological data were collected and statistically analyzed.<jats:italic> Results<\/jats:italic>. Our results confirm the relevant difference of FP thickness, particularly represented under the endometrium for submucous LMs. FPs near the endometrial cavity were considerably thicker than those of both intramural fibroids and subserous fibroids measured by US (P=0.0001) and histology (P=0.0001). A clear cut-off measurement at 2\u2009mm (P=0.0001) was found between endometrial FPs and all other FPs for either US or histology measurements.<jats:italic> Conclusion<\/jats:italic>. The thickness of FP is considerably higher near the endometrial cavity when compared to those of both intramural and subserous LMs, suggesting a potential role either in fertility or in myometrial healing.<\/jats:p>","DOI":"10.1155\/2018\/2804830","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T19:30:52Z","timestamp":1536003052000},"page":"1-7","source":"Crossref","is-referenced-by-count":20,"title":["Submucous Fibroids, Fertility, and Possible Correlation to Pseudocapsule Thickness in Reproductive Surgery"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8426-8490","authenticated-orcid":true,"given":"Andrea","family":"Tinelli","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Experimental Endoscopic Surgery, Imaging, Technology and Minimally Invasive Therapy, Vito Fazzi Hospital, P.zza Muratore, Lecce, Italy"},{"name":"Laboratory of Human Physiology, Phystech BioMed School, Faculty of Biological & Medical Physics, Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5662-5566","authenticated-orcid":true,"given":"Ioannis","family":"Kosmas","sequence":"additional","affiliation":[{"name":"Laboratory of Human Physiology, Phystech BioMed School, Faculty of Biological & Medical Physics, Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow Region, Russia"},{"name":"Department of Obstetrics and Gynecology, University of Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9309-1938","authenticated-orcid":true,"given":"Ospan A.","family":"Mynbaev","sequence":"additional","affiliation":[{"name":"Laboratory of Human Physiology, Phystech BioMed School, Faculty of Biological & Medical Physics, Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow Region, Russia"},{"name":"Division of Molecular Technologies, Research Institute of Translational Medicine, N.I. 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