{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T17:55:33Z","timestamp":1786902933036,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"vor","delay-in-days":287,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background.<\/jats:italic>\n                    Interstitial pregnancy is a rare form of ectopic pregnancy that usually leads to uterine rupture resulting in sudden life\u2010threatening haemorrhage, need for blood transfusion, and admission to intensive care unit. Mortality rate is 6\u20137 times higher than that in classical ectopic pregnancy. Uterine rupture has been typically reported to occur at more advanced gestational ages compared to tubal pregnancy although several recent reports have shown a high risk of rupture before 12 weeks of gestation.\n                    <jats:italic>Cases Presentation.<\/jats:italic>\n                    We report three cases of women affected by interstitial pregnancy, with different clinical symptoms, and managed to be treated with surgery or medical therapy. An emergency laparotomy was performed in the first case by the general surgeon, while in the second case laparoscopy was made by a gynecologist; last case shows the success of systemic administration of methotrexate.\n                    <jats:italic>Conclusion.<\/jats:italic>\n                    Interstitial pregnancy is still a challenging condition to diagnose and treat; early diagnosis may help to choose the proper management.\n                  <\/jats:p>","DOI":"10.1155\/2018\/2815871","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T19:30:41Z","timestamp":1539631841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Interstitial Pregnancy: From Medical to Surgical Approach\u2014Report of Three Cases"],"prefix":"10.1155","volume":"2018","author":[{"given":"L.","family":"Di Tizio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0213-1085","authenticated-orcid":false,"given":"M. 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