{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:11:42Z","timestamp":1787847102328,"version":"build-2784847793"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    The injection of the traditional Chinese patent medicine puerarin has been widely used in the treatment of various diseases such as angina pectoris or ischemic stroke. We aim to evaluate the efficacy and safety of puerarin injection for the treatment of diabetic peripheral neuropathy (DPN).\n                    <jats:italic>Methods.<\/jats:italic>\n                    A systematic literature search was performed in seven medical databases from their inception until June 2017. 53 studies with RCTs, totaling 3284 patients, were included in this meta\u2010analysis. The included studies were assessed by the Cochrane risk of bias and analyzed by Review Manager 5.3 software.\n                    <jats:italic>Results.<\/jats:italic>\n                    The meta\u2010analysis showed that puerarin injection for the treatment of DPN was significantly better compared with the control group in terms of the total effective rate. The result showed that puerarin injection for the treatment of DPN can significantly increase the probability of sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) of the median and peroneal nerves.\n                    <jats:italic>Conclusions.<\/jats:italic>\n                    This meta\u2010analysis demonstrated that puerarin injection may be more effective and safe for the treatment of DPN. However, further and higher quality RCTs are required to prove its efficacy and provide meaningful evidence for clinical treatment due to the poor methodological quality.\n                  <\/jats:p>","DOI":"10.1155\/2018\/2834650","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T18:30:42Z","timestamp":1516818642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy and Safety of the Injection of the Traditional Chinese Medicine Puerarin for the Treatment of Diabetic Peripheral Neuropathy: A Systematic Review and Meta\u2010Analysis of 53 Randomized Controlled Trials"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7109-402X","authenticated-orcid":false,"given":"Baocheng","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9696-3543","authenticated-orcid":false,"given":"Qinghui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2232-8413","authenticated-orcid":false,"given":"Chenhui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1494-223X","authenticated-orcid":false,"given":"Jiahuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6449-4298","authenticated-orcid":false,"given":"Daohua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000465"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1964"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1790"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1089-6"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53480-4.00037-0"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53480-4.00016-3"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0254-6272(15)30039-x"},{"key":"e_1_2_9_8_2","first-page":"22","article-title":"Puerarin injection combined with scopolamine in treatment of diabetic peripheral neuropathy","author":"Zheng W.","year":"2006","journal-title":"Medicine World"},{"key":"e_1_2_9_9_2","first-page":"128","article-title":"Effect of puerarin and methylcobalamin in injection on diabetic peripheral neuropathy","volume":"18","author":"Wang Y. 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