{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:31:07Z","timestamp":1759336267239,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T00:00:00Z","timestamp":1542499200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"RTS (Renal Therapy Service)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Nephrology"],"published-print":{"date-parts":[[2018,11,18]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic> Acid-base disorders have been previously described in patients with chronic hemodialysis, with metabolic acidosis being the most important of them; however, little is known about the potential changes in acid-base status of patients on dialysis living at high altitudes.<jats:italic> Methods.<\/jats:italic> Cross-sectional study including 93 patients receiving chronic hemodialysis on alternate days and living in Bogot\u00e1, Colombia, at an elevation of 2,640 meters (8,661 feet) over sea level (m.o.s.l.). Measurements of pH, PaCO<jats:sub>2<\/jats:sub>, HCO<jats:sub>3<\/jats:sub>, PO<jats:sub>2<\/jats:sub>, and base excess were made on blood samples taken from the arteriovenous fistula (AVF) during the pre- and postdialysis periods in the midweek hemodialysis session. Normal values for the altitude of Bogot\u00e1 were taken into consideration for the interpretation of the arterial blood gases.<jats:italic> Results.<\/jats:italic> 43% (n= 40) of patients showed predialysis normal acid-base status. The most common acid-base disorder in predialysis period was metabolic alkalosis with chronic hydrogen ion deficiency in 19,3% (n=18). Only 9,7% (n=9) had predialysis metabolic acidosis. When comparing pre- and postdialysis blood gas analysis, higher postdialysis levels of pH (7,41 versus 7,50, p&lt;0,01), bicarbonate (21,7mmol\/L versus 25,4mmol\/L, p&lt;0,01), and base excess (-2,8 versus 2,4, p&lt;0,01) were reported, with lower levels of partial pressure of carbon dioxide (34,9 mmHg versus 32,5 mmHg, p&lt;0,01).<jats:italic> Conclusion.<\/jats:italic> At an elevation of 2,640 m.o.s.l., a large percentage of patients are in normal acid-base status prior to the dialysis session (\u201cpredialysis period\u201d). Metabolic alkalosis is more common than metabolic acidosis in the predialysis period when compared to previous studies. Paradoxically, despite postdialysis metabolic alkalosis, PaCO<jats:sub>2<\/jats:sub> levels are lower than those found in the predialysis period.<\/jats:p>","DOI":"10.1155\/2018\/2872381","type":"journal-article","created":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T18:33:35Z","timestamp":1542566015000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["Acid-Base Status Disturbances in Patients on Chronic Hemodialysis at High Altitudes"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6544-1497","authenticated-orcid":true,"given":"Javier Enrique","family":"Cely","sequence":"first","affiliation":[{"name":"Renal Therapy Service (RTS), Bogot\u00e1 110221, Colombia"},{"name":"Hospital Universitario Nacional de Colombia, 111321 Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar G.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Renal Therapy Service (RTS), Bogot\u00e1 110221, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda J.","family":"Vargas","sequence":"additional","affiliation":[{"name":"Renal Therapy Service (RTS), Bogot\u00e1 110221, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael M.","family":"Sanabria","sequence":"additional","affiliation":[{"name":"Renal Therapy Service (RTS), Bogot\u00e1 110221, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyder","family":"Corzo","sequence":"additional","affiliation":[{"name":"Renal Therapy Service (RTS), Bogot\u00e1 110221, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto E.","family":"D'Achiardi","sequence":"additional","affiliation":[{"name":"Renal Therapy Service (RTS), Bogot\u00e1 110221, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo A.","family":"Z\u00fa\u00f1iga","sequence":"additional","affiliation":[{"name":"Renal Therapy Service (RTS), Bogot\u00e1 110221, Colombia"},{"name":"Hospital Universitario Nacional de Colombia, 111321 Bogot\u00e1, Colombia"},{"name":"Assistant Professor, Internal Medicine Department, Universidad Nacional de Colombia, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.162"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12659"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.06.008"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.04.014"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00010505"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw022"},{"key":"7","first-page":"155","volume":"4","year":"2005","journal-title":"Journal of physiology and pharmacology"},{"issue":"1","key":"8","first-page":"13","volume":"8","year":"1983","journal-title":"Acta m\u00e9d. colomb"},{"first-page":"A4852","volume-title":"Reference Values for Arterial Blood Gases at an Altitude of 2640 Meters","year":"2013","key":"9"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3109\/00365516309079734"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.30789\/rcneumologia.v26.n1.2014.56"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-010-0088-9"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12129"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12682"}],"container-title":["International Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijn\/2018\/2872381.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijn\/2018\/2872381.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijn\/2018\/2872381.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T18:33:38Z","timestamp":1542566018000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijn\/2018\/2872381\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,18]]},"references-count":14,"alternative-id":["2872381","2872381"],"URL":"https:\/\/doi.org\/10.1155\/2018\/2872381","relation":{},"ISSN":["2090-214X","2090-2158"],"issn-type":[{"type":"print","value":"2090-214X"},{"type":"electronic","value":"2090-2158"}],"subject":[],"published":{"date-parts":[[2018,11,18]]}}}