{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:59:15Z","timestamp":1763535555501,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,8,5]],"date-time":"2018-08-05T00:00:00Z","timestamp":1533427200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis"],"published-print":{"date-parts":[[2018,8,5]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Ankylosing spondylitis (AS) is a chronic, progressive inflammatory rheumatic disease that leads to structural damage, functional impairment, and decrease in the quality of life. Red cell distribution width (RDW) is a part of the complete blood count (CBC) and estimates erythrocyte variability.<jats:italic>Objective<\/jats:italic>. To analyse RDW in patients with AS and to evaluate the relationships with acute phase reactants (APRs) and disease activity index.<jats:italic>Patients and Methods<\/jats:italic>. A total of 100 patients with AS (78 males and 22 females) were diagnosed according to the modified New York classification criteria for AS and 146 (99 males: 47 females) healthy individuals matched in age and sex as controls enrolled in the study. Demographic data, disease activity scores using Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), medical history, C-reactive protein (CRP), erythrocytes sedimentation rate (ESR), and complete blood count (CBC) were measured.<jats:italic>Results<\/jats:italic>. The mean age for patients and controls was 38.0 \u00b1 9.0 and 35.8 \u00b1 9.0 years, respectively (p=0.057). RDW was significantly higher in patients with AS compared with controls (14.133 \u00b1 1.613 versus 12.299 \u00b1 1.031, p &lt; 0.001). There was a direct correlation of RDW with both ESR and CRP (P &lt; 0.001); RDW had r=0.38 for C-reactive protein (CRP) and r=0.413 for ESR. Also BASDAI was directly correlated with RDW (r=0.326 p&lt;0.001). RDW was a valid measure to differentiate between patients with AS and controls (AUC=0,84, p&lt;0.001) and at optimum cut-off value&gt;13% has highest accuracy (78.9%) with very good sensitivity test (81%) and NPV (85.6%) as well as good specificity (77.4%) and PPV (71.1%).<jats:italic>Conclusion<\/jats:italic>. RDW was higher in AS patients compared with controls and was directly correlated with ESR, CRP, and BASDAI. RDW was a valid simple measure with good accuracy to differentiate between patients with AS and controls.<\/jats:p>","DOI":"10.1155\/2018\/2904694","type":"journal-article","created":{"date-parts":[[2018,8,5]],"date-time":"2018-08-05T23:31:32Z","timestamp":1533511892000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic Performance of Red Cell Distribution Width in Adult Iraqi Patients with Ankylosing Spondylitis"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2760-5566","authenticated-orcid":true,"given":"Faiq I.","family":"Gorial","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Medicine, Collage of Medicine, University of Bagdad, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali M.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Baghdad Teaching Hospital, Rheumatology Unit, Baghdad, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/860213"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120403"},{"year":"2007","key":"4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553x.2009.01160.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1309\/CQGG-HY0U-LRKL-GLMP"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1309\/LY7YLUPE7551JYBG"},{"issue":"4","key":"8","doi-asserted-by":"crossref","first-page":"628","DOI":"10.5858\/133.4.628","volume":"133","year":"2009","journal-title":"Archives of Pathology & Laboratory Medicine"},{"key":"9","first-page":"505","volume":"134","year":"2010","journal-title":"Archives of Pathology & Laboratory Medicine"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0436-2"},{"key":"11","first-page":"9","volume":"3","year":"2012","journal-title":"Journal of Clinical & Experimental Cardiology"},{"key":"12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.cca.2013.08.007","volume":"425","year":"2013","journal-title":"Clinica Chimica Acta"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.104018"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.9.878"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.06.033"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70038-7"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380407"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.037465"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2002.35927"},{"issue":"12","key":"21","first-page":"5289","volume":"7","year":"2014","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1978-2"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31825e2a85"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3233\/CH-162067"}],"container-title":["Arthritis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2018\/2904694.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2018\/2904694.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2018\/2904694.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T19:48:33Z","timestamp":1661716113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/arthritis\/2018\/2904694\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,5]]},"references-count":24,"alternative-id":["2904694","2904694"],"URL":"https:\/\/doi.org\/10.1155\/2018\/2904694","relation":{},"ISSN":["2090-1984","2090-1992"],"issn-type":[{"type":"print","value":"2090-1984"},{"type":"electronic","value":"2090-1992"}],"subject":[],"published":{"date-parts":[[2018,8,5]]}}}