{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:28:51Z","timestamp":1784050131357,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2018,12,3]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Prehospital management of traumatic pain is commonly based on morphine while locoregional analgesia techniques, especially the femoral nerve block (FNB), can be safely and efficiently used. Adjuvants uses can reduce local anesthetic doses and decrease their related risk. The aim of the study was to assess the analgesic effect of magnesium sulfate when used as an adjuvant in prehospital FNB. <jats:italic>Methods<\/jats:italic>. This is a randomized double-blinded trial conducted in a prehospital medical department of an academic hospital. Patients with isolated diaphysial femoral fracture and eligible to participate were randomized into 2 groups. Group C had a FNB with 15\u2009ml of lidocaine with epinephrine (300\u2009mg) and 3\u2009ml of normal saline solution. Group I had a FNB with 15\u2009ml of lidocaine with epinephrine (300\u2009mg) and 3\u2009ml of MgS 15% (450\u2009mg). The FNB was performed according to the WINNIE technique. Primary endpoints were morphine consumption and pain intensity during the first 6 hours. Secondary endpoints were the duration of the sensory block, time to the first analgesic request, and side effects occurrence. <jats:italic>Results<\/jats:italic>. Twenty-four patients were enrolled in each group<jats:bold>.<\/jats:bold> Both groups were comparable according to demographic characteristics, initial pain scores, and vital constants. In group I, morphine requirements were significantly lower (2 \u00b1 2\u2009mg versus 5 \u00b1 3\u2009mg, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:msup><mml:mrow><mml:mn>10<\/mml:mn><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><mml:mn>3<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>), analgesic onset was significantly faster, and the average time to the first analgesic request was longer (276 \u00b1 139\u2009min versus 160 \u00b1 79\u2009min, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:msup><mml:mrow><mml:mn>10<\/mml:mn><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><mml:mn>3<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>). The average duration of sensory block was longer in group I (226 \u00b1 64\u2009min versus 116 \u00b1 70\u2009min <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:msup><mml:mrow><mml:mn>10<\/mml:mn><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><mml:mn>3<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>). No side effects were recorded. <jats:italic>Conclusion<\/jats:italic>. Magnesium sulfate should be considered as an efficient and safe adjuvant to lidocaine in prehospital FNB. This trial is registered with (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03597945\">NCT03597945<\/jats:ext-link>).<\/jats:p>","DOI":"10.1155\/2018\/2926404","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T18:30:44Z","timestamp":1543861844000},"page":"1-5","source":"Crossref","is-referenced-by-count":14,"title":["Magnesium Sulfate as Adjuvant in Prehospital Femoral Nerve Block for a Patient with Diaphysial Femoral Fracture: A Randomized Controlled Trial"],"prefix":"10.1155","volume":"2018","author":[{"given":"Chawki","family":"Jebali","sequence":"first","affiliation":[{"name":"Emergency Medical Service, Sahloul Academic Hospital, Sousse, Tunisia"},{"name":"University of Medicine \u00ab Ibn Al Jazzar \u00bb, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9646-7451","authenticated-orcid":true,"given":"Mohamed","family":"Kahloul","sequence":"additional","affiliation":[{"name":"University of Medicine \u00ab Ibn Al Jazzar \u00bb, Sousse, Tunisia"},{"name":"Department of Anesthesia and Intensive Care, Sahloul Academic Hospital, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrine Ibn","family":"Hassine","sequence":"additional","affiliation":[{"name":"University of Medicine \u00ab Ibn Al Jazzar \u00bb, Sousse, Tunisia"},{"name":"Emergency Department, Ibn Al Jazzar Academic Hospital, Kairouan, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Aymen","family":"Jaouadi","sequence":"additional","affiliation":[{"name":"Emergency Medical Service, Sahloul Academic Hospital, Sousse, Tunisia"},{"name":"University of Medicine \u00ab Ibn Al Jazzar \u00bb, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fehmi","family":"Ferhi","sequence":"additional","affiliation":[{"name":"University of Medicine \u00ab Ibn Al Jazzar \u00bb, Sousse, Tunisia"},{"name":"Department of Anesthesia and Intensive Care, Farhat Hachad Academic Hospital, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Naija","sequence":"additional","affiliation":[{"name":"University of Medicine \u00ab Ibn Al Jazzar \u00bb, Sousse, Tunisia"},{"name":"Department of Anesthesia and Intensive Care, Sahloul Academic Hospital, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoufel","family":"Chebili","sequence":"additional","affiliation":[{"name":"Emergency Medical Service, Sahloul Academic Hospital, Sousse, Tunisia"},{"name":"University of Medicine \u00ab Ibn Al Jazzar \u00bb, Sousse, 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