{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:15:11Z","timestamp":1777389311215,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T00:00:00Z","timestamp":1545782400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871653"],"award-info":[{"award-number":["81871653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CXTDX201601015"],"award-info":[{"award-number":["CXTDX201601015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["cstc2016jcyjA0269"],"award-info":[{"award-number":["cstc2016jcyjA0269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program for Innovation Team of Higher Education in Chongqing","award":["81871653"],"award-info":[{"award-number":["81871653"]}]},{"name":"Program for Innovation Team of Higher Education in Chongqing","award":["CXTDX201601015"],"award-info":[{"award-number":["CXTDX201601015"]}]},{"name":"Program for Innovation Team of Higher Education in Chongqing","award":["cstc2016jcyjA0269"],"award-info":[{"award-number":["cstc2016jcyjA0269"]}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["81871653"],"award-info":[{"award-number":["81871653"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["CXTDX201601015"],"award-info":[{"award-number":["CXTDX201601015"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["cstc2016jcyjA0269"],"award-info":[{"award-number":["cstc2016jcyjA0269"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,12,26]]},"abstract":"<jats:p>Hepatitis B virus (HBV) is an important public health problem that poses a serious threat to human health. HBV reactivation generally occurs in overt or occult HBV infection patients who suffered DDAs, chemotherapy, or immunosuppressive therapy, especially when some solid tumors and leukemia patients are using hormones such as prednisolone and imatinib. The approximate incidence of HBV reactivation ranged from about 10% to 40%. Scientists often explore the molecular mechanisms from both the virus and the host. But some studies have reported that some drugs (cisplatin, rituximab, imatinib, and glucocorticoid) could induce HBV reactivation directly. However, the specific molecular mechanisms were unclear. With the emergence of new antiviral drugs and molecular targeted drugs, the risk of HBV reactivation will increase significantly. Therefore this review was expected to be used to provide recommendations for future research in HBV reactivation.<\/jats:p>","DOI":"10.1155\/2018\/2931402","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T18:30:25Z","timestamp":1545849025000},"page":"1-9","source":"Crossref","is-referenced-by-count":27,"title":["Recent Advances in HBV Reactivation Research"],"prefix":"10.1155","volume":"2018","author":[{"given":"Lixia","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun 130041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The People\u2019s Hospital of Rongchang District, Chongqing 402460, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiping","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Molecular Medicine Testing Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6754-4331","authenticated-orcid":true,"given":"Hongquan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun 130041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5533-7995","authenticated-orcid":true,"given":"Xiaosong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Chongqing Medical University, Chongqing 400016, China"},{"name":"Clinical Molecular Medicine Testing Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02423.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3449"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2961"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-011-9279-6"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-14-31"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-015-9612-6"},{"issue":"2","key":"7","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jhep.2017.03.021","volume":"67","year":"2017","journal-title":"Journal of Hepatology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.10.038"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.02.009"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq583"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-10-201205150-00013"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26718"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12513"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22945"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-014-9542-8"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25241"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1177\/1078155218782614"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.13050"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29109"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i28.3181"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.06.023"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29135"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.11.011"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.7326\/M17-0377"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1177\/1078155218790337"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3405-7"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v10.i7.509"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201316"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1159\/000490099"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-7-200804010-00008"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913498107"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.208413"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06429.x"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2013.7.2.197"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25636"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-012-9381-4"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis569"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1187-z"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28156"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21847-3"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.7510"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27716"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.10.039"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12269"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.04.036"},{"issue":"1","key":"48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12072-015-9675-4","volume":"10","year":"2016","journal-title":"Hepatology International"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2018.1505501"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.3795"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.02.033"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29082"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27609"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14662"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/2931402.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/2931402.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/2931402.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T18:30:28Z","timestamp":1545849028000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/2931402\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,26]]},"references-count":52,"alternative-id":["2931402","2931402"],"URL":"https:\/\/doi.org\/10.1155\/2018\/2931402","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,26]]}}}