{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:23Z","timestamp":1787017703447,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,8]],"date-time":"2018-07-08T00:00:00Z","timestamp":1531008000000},"content-version":"vor","delay-in-days":188,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004686","name":"Deanship of Scientific Research, King Faisal University","doi-asserted-by":"publisher","award":["RGP-073"],"award-info":[{"award-number":["RGP-073"]}],"id":[{"id":"10.13039\/501100004686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    Tuberculosis (TB) remains a common deadly infectious disease and worldwide a major health problem. The current study was therefore designed to investigate the\n                    <jats:italic>in vitro<\/jats:italic>\n                    antimycobacterial activity of different extracts of\n                    <jats:italic>Alpinia galanga<\/jats:italic>\n                    and\n                    <jats:italic>Tinospora cordifolia<\/jats:italic>\n                    . Moreover, a safety assessment for both plants was carried out. Dichloromethane and ethanolic extracts of each plant were examined against H37Rv INH\u2010sensitive and resistant INH strains of\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    . The safety assessment of both plants has been performed through\n                    <jats:italic>in vivo<\/jats:italic>\n                    acute and chronic toxicity studies in animal model. Body weight, food consumption, water intake, organ\u2019s weight, and haematological and biochemical parameters of blood and serum were evaluated. The extracts of\n                    <jats:italic>A. galanga<\/jats:italic>\n                    and\n                    <jats:italic>T. cordifolia<\/jats:italic>\n                    produced significant and dose\u2010dependent inhibitory activity with maximum effect of 18\u201032% at 50\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/ml against both strains of\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    . No effect on the body weight or food and water consumption was observed but\n                    <jats:italic>A. galanga<\/jats:italic>\n                    caused significantly an increase in the relative weight of the heart, liver, spleen, and kidney. Haematological studies of both plants revealed a slight but significant fall in the RBC and WBC level as well as haemoglobin and platelets. In addition,\n                    <jats:italic>A. galanga<\/jats:italic>\n                    extracts increased significantly liver enzymes and bilirubin and glucose.\n                  <\/jats:p>","DOI":"10.1155\/2018\/2934583","type":"journal-article","created":{"date-parts":[[2018,7,8]],"date-time":"2018-07-08T19:31:18Z","timestamp":1531078278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antimycobacterial Activity and Safety Profile Assessment of\n                    <i>Alpinia galanga<\/i>\n                    and\n                    <i>Tinospora cordifolia<\/i>"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3044-1267","authenticated-orcid":false,"given":"Mohamed F.","family":"Alajmi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4220-7854","authenticated-orcid":false,"given":"Ramzi A.","family":"Mothana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan J.","family":"Al-Rehaily","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2442-0790","authenticated-orcid":false,"given":"Jamal M.","family":"Khaled","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,8]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/403623"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2850845"},{"key":"e_1_2_10_3_2","unstructured":"OrganizationW. 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