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Unfortunately, clinical diagnosis is usually performed at an advanced disease stage when dementia is established, making implementation of successful therapeutic interventions difficult. Current biomarkers tend to be expensive, insufficient, or invasive, raising the need for novel, improved tools aimed at early disease detection. AD is characterized by brain atrophy due to neuronal and synaptic loss, extracellular amyloid plaques composed of amyloid-beta peptide (A<jats:italic>\u03b2<\/jats:italic>), and neurofibrillary tangles of hyperphosphorylated tau protein. The visual system and central nervous system share many functional components. Thus, it is plausible that damage induced by A<jats:italic>\u03b2<\/jats:italic>, tau, and neuroinflammation may be observed in visual components such as the retina, even at an early disease stage. This underscores the importance of implementing ophthalmological examinations, less invasive and expensive than other biomarkers, as useful measures to assess disease progression and severity in individuals with or at risk of AD. Here, we review functional and morphological changes of the retina and visual pathway in AD from pathophysiological and clinical perspectives.<\/jats:p>","DOI":"10.1155\/2018\/2941783","type":"journal-article","created":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T19:30:49Z","timestamp":1539545449000},"page":"1-21","source":"Crossref","is-referenced-by-count":44,"title":["Visual Features in Alzheimer\u2019s Disease: From Basic Mechanisms to Clinical Overview"],"prefix":"10.1155","volume":"2018","author":[{"given":"Mar\u00eda Alejandra","family":"Cerquera-Jaramillo","sequence":"first","affiliation":[{"name":"Escuela Superior de Oftalmolog\u00eda-Instituto Barraquer de Am\u00e9rica, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio O.","family":"Nava-Mesa","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Neurociencias (NeURos), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, 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