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To evaluate the regulating effect of Notch1 signaling on Th17\/Treg immune imbalance in psoriasis vulgaris (PV). <jats:italic>Materials and Methods<\/jats:italic>. Notch1, Hes-1, ROR<jats:italic>\u03b3<\/jats:italic>t, Foxp3, IL-17, and IL-10 mRNA expression, as well as Th17 and Treg cell percentages in peripheral CD4<jats:sup>+<\/jats:sup> T cells, were detected by real-time quantitative RT-PCR and flow cytometry, and serum concentrations of IL-17 and IL-10 were detected by ELISA in 36 PV patients and 32 healthy controls. Additionally, CD4<jats:sup>+<\/jats:sup> T cells from 12 PV patients were treated with <jats:italic>\u03b3<\/jats:italic>-secretase inhibitor DAPT, and the above indexes were measured. <jats:italic>Results<\/jats:italic>. PV patients presented distinct Th17\/Treg immune imbalance and highly expressed Notch1 and Hes-1 mRNA levels, which were positively correlated with psoriasis area and severity index (PASI) and the ratios of Th17\/Treg and ROR<jats:italic>\u03b3<\/jats:italic>t\/Foxp3. DAPT treatment resulted in the obvious downregulation of Th17 cell percentage in cocultured CD4<jats:sup>+<\/jats:sup> T cells, ROR<jats:italic>\u03b3<\/jats:italic>t and IL-17 mRNA levels, and IL-17 concentration in cell-free supernatant from cocultured CD4<jats:sup>+<\/jats:sup> T cells of PV patients in a dose-dependent manner, while there was no significant influence on Treg cell percentage, Foxp3, and IL-10 expression, therefore leading to the recovery of Th17\/Treg immune imbalance. <jats:italic>Conclusion<\/jats:italic>. Notch1 signaling may contribute to the pathogenesis of PV by regulating Th17\/Treg immune imbalance.<\/jats:p>","DOI":"10.1155\/2018\/3069521","type":"journal-article","created":{"date-parts":[[2018,3,4]],"date-time":"2018-03-04T23:31:04Z","timestamp":1520206264000},"page":"1-10","source":"Crossref","is-referenced-by-count":41,"title":["Notch1 Signaling Regulates the Th17\/Treg Immune Imbalance in Patients with Psoriasis Vulgaris"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-3242","authenticated-orcid":true,"given":"Lei","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Dermatology, Binzhou Medical University Hospital, 661 Second Huanghe Road, Binzhou 256603, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0495-3349","authenticated-orcid":true,"given":"HaiBo","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, 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