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The present study was designed to determine whether dexmedetomidine (DEX) exerts cardioprotection against myocardial I\/R injury in diabetic hearts and the mechanisms involved. <jats:italic>Methods<\/jats:italic>. A total of 30 diabetic rats induced by high-glucose-fat diet and streptozotocin (STZ) were randomly assigned to five groups: diabetic sham-operated group (DM-S), diabetic I\/R group (DM-I\/R), diabetic DEX group (DM-D), diabetic DEX\u2009+\u2009Wort group (DM-DW), and diabetic Wort group (DM-W). Another 12 age-matched male normal SD rats were randomly divided into two groups: sham-operated group (S) and I\/R group (I\/R). All rats were subjected to 30\u2009min myocardial ischemia followed by 120\u2009min reperfusion except sham groups. Plasmas were collected to measure the malondialdehyde (MDA), creatine kinase isoenzymes (CK-MB), and lactate dehydrogenase (LDH) levels and superoxide dismutase (SOD) activity at the end of reperfusion. Pathologic changes in myocardial tissues were observed by H-E staining. The total and phosphorylated form of Akt and GSK-3<jats:italic>\u03b2<\/jats:italic> protein expressions were measured by western blot. The ratio of Bcl-2\/Bax at mRNA level was detected by reverse transcription-polymerase chain reaction (RT-PCR). <jats:italic>Results<\/jats:italic>. DEX significantly reduced plasma CK-MB, MDA concentration, and LDH level and increased SOD activity caused by I\/R. The phosphorylation of Akt and GSK-3<jats:italic>\u03b2<\/jats:italic> was increased, Bcl-2 mRNA and the Bcl-2\/Bax ratio was increased, and Bax mRNA was decreased in the DEX group as compared to the I\/R group, while posttreatment with Wort attenuated the effects induced by DEX. <jats:italic>Conclusion<\/jats:italic>. The results of this study suggest that DEX postconditioning may increase the phosphorylation of GSK-3<jats:italic>\u03b2<\/jats:italic> by activating the PI3K\/Akt signaling pathway and may inhibit apoptosis and oxidative stress of the myocardium, thus exerting protective effects in diabetic rat hearts suffering from I\/R injury.<\/jats:p>","DOI":"10.1155\/2018\/3071959","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T19:36:05Z","timestamp":1539027365000},"page":"1-10","source":"Crossref","is-referenced-by-count":47,"title":["Effects of Dexmedetomidine Postconditioning on Myocardial Ischemia\/Reperfusion Injury in Diabetic Rats: Role of the PI3K\/Akt-Dependent Signaling Pathway"],"prefix":"10.1155","volume":"2018","author":[{"given":"Xiangyang","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, 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