{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:50:04Z","timestamp":1785426604220,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004386","name":"Universiti Malaya","doi-asserted-by":"publisher","award":["RG35211HTM"],"award-info":[{"award-number":["RG35211HTM"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Nephrology"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. To assess the performance of different GFR estimating equations, test the diagnostic value of serum cystatin-C, and compare the applicability of cystatin-C based equation with serum creatinine based equation for estimating GFR (eGFR) in comparison with measured GFR in the elderly Malaysian patients.<jats:italic>Methods<\/jats:italic>. A cross-sectional study recruiting volunteered patients 65 years and older attending medical outpatient clinic. 51 chromium EDTA (<jats:sup>51<\/jats:sup>Cr-EDTA) was used as measured GFR. The predictive capabilities of Cockcroft-Gault equation corrected for body surface area (CGBSA), four-variable Modification of Diet in Renal Disease (4-MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations using serum creatinine (CKD-EPIcr) as well as serum cystatin-C (CKD-EPIcys) were calculated.<jats:italic>Results<\/jats:italic>. A total of 40 patients, 77.5% male, with mean measured GFR<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn fontstyle=\"italic\">41.2<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">18.9<\/mml:mn><\/mml:math>\u2009ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>were enrolled. Mean bias was the smallest for 4-MDRD; meanwhile, CKD-EPIcr had the highest precision and accuracy with lower limit of agreement among other equations. CKD-EPIcys equation did not show any improvement in GFR estimation in comparison to CKD-EPIcr and MDRD.<jats:italic>Conclusion<\/jats:italic>. The CKD-EPIcr formula appears to be more accurate and correlates better with measured GFR in this cohort of elderly patients.<\/jats:p>","DOI":"10.1155\/2018\/3081518","type":"journal-article","created":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T23:30:44Z","timestamp":1526254244000},"page":"1-6","source":"Crossref","is-referenced-by-count":5,"title":["Estimating Renal Function in the Elderly Malaysian Patients Attending Medical Outpatient Clinic: A Comparison between Creatinine Based and Cystatin-C Based Equations"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9198-8306","authenticated-orcid":true,"given":"Maisarah","family":"Jalalonmuhali","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Malaya Medical Centre, 59100 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma Mohamed Abouzriba","family":"Elagel","sequence":"additional","affiliation":[{"name":"Management and Science University, 40100 Shah Alam, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maw Pin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Malaya Medical Centre, 59100 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Kun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Malaya Medical Centre, 59100 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Peng","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Malaya Medical Centre, 59100 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2217\/cpr.14.46"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.3.356"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004060447"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1080\/00365519850186210"},{"issue":"4","key":"8","first-page":"387","volume":"36","year":"2006","journal-title":"Annals of Clinical & Laboratory Science"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.34487"},{"issue":"8","key":"10","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1093\/clinchem\/29.8.1494","volume":"29","year":"1983","journal-title":"Clinical Chemistry"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg349"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afr033"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq091"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1159\/000355568"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1080\/03610730802545051"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afj041"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.03.026"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199403313301301"},{"key":"19","first-page":"63","volume":"35","year":"2000","journal-title":"Advances in Clinical Chemistry"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3109\/00365519609088795"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1995.tb00275.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.06.016"}],"container-title":["International Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijn\/2018\/3081518.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijn\/2018\/3081518.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijn\/2018\/3081518.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T22:48:33Z","timestamp":1604270913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijn\/2018\/3081518\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":21,"alternative-id":["3081518","3081518"],"URL":"https:\/\/doi.org\/10.1155\/2018\/3081518","relation":{},"ISSN":["2090-214X","2090-2158"],"issn-type":[{"value":"2090-214X","type":"print"},{"value":"2090-2158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}