{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:33:45Z","timestamp":1768736025739,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,2,25]],"date-time":"2018-02-25T00:00:00Z","timestamp":1519516800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["17DZ2260100"],"award-info":[{"award-number":["17DZ2260100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["81670868"],"award-info":[{"award-number":["81670868"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["17DZ2260100"],"award-info":[{"award-number":["17DZ2260100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670868"],"award-info":[{"award-number":["81670868"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2018,2,25]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To examine the changes in retinal thickness of patients with diabetes without DR. <jats:italic>Designs<\/jats:italic>. A randomization, crossover, retrospective practice. <jats:italic>Participants<\/jats:italic>. 43 diabetic patients and 43 ethnic-, age-, and sex-matched controls. <jats:italic>Methods<\/jats:italic>. Full retinal thicknesses of ten areas were assessed using spectral domain optical coherence tomography. Confounding variables, such as age, gender, and glycated haemoglobin (HbA1c) level, were assessed by regression analysis. <jats:italic>Main Outcome Measures<\/jats:italic>. Mean retinal thickness of ten areas. <jats:italic>Results<\/jats:italic>. The mean thickness of the fovea was 215.8\u2009\u00b1\u200918.9\u2009<jats:italic>\u03bc<\/jats:italic>m in the diabetes group and 222.0\u2009\u00b1\u200918.6\u2009<jats:italic>\u03bc<\/jats:italic>m in the control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:math>). The mean thickness of the temporal parafovea was 319.9\u2009\u00b1\u200916.7\u2009<jats:italic>\u03bc<\/jats:italic>m in the diabetes group and 326.0\u2009\u00b1\u200914.4\u2009<jats:italic>\u03bc<\/jats:italic>m in the control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). The mean thickness of the temporal perifovea was 276.4\u2009\u00b1\u200927.9\u2009<jats:italic>\u03bc<\/jats:italic>m in the diabetes group and 284.8\u2009\u00b1\u200917.4\u2009<jats:italic>\u03bc<\/jats:italic>m in the control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>). There were no significant differences in retinal thickness between groups in other areas (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Regression analysis revealed that decreased retinal thickness of the temporal perifovea was associated with a higher HbA1c level (&gt;8.7%) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:math>). <jats:italic>Conclusion and Relevance<\/jats:italic>. Subtle structural changes in the retina may occur in diabetes without DR. Decreased retinal thickness appeared to begin in the fovea and temporal areas. A high HbA1c level was the main factor influencing retinal thickness.<\/jats:p>","DOI":"10.1155\/2018\/3082893","type":"journal-article","created":{"date-parts":[[2018,2,25]],"date-time":"2018-02-25T18:30:42Z","timestamp":1519583442000},"page":"1-7","source":"Crossref","is-referenced-by-count":31,"title":["Analysis of Changes in Retinal Thickness in Type 2 Diabetes without Diabetic Retinopathy"],"prefix":"10.1155","volume":"2018","author":[{"given":"Jing","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Department of Ophthalmology, Huashan Hospital of Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingchao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Huashan Hospital of Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0948-5855","authenticated-orcid":true,"given":"Dongqing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0944-8584","authenticated-orcid":true,"given":"Zhiliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Huashan Hospital of Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9281-9221","authenticated-orcid":true,"given":"Xiaofang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth 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