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To date, over 145 loci have been identified to cause nonsyndromic deafness. Furthermore, there are countless families unsuitable for the conventional linkage analysis. In the present study, we used a custom capture panel (MiamiOtoGenes) to target sequence 180 deafness-associated genes in 5<jats:italic> GJB2<\/jats:italic> negative deaf probands with autosomal recessive nonsyndromic HL from Iran. In these 5 families, we detected one reported and six novel mutations in 5 different deafness autosomal recessive (DFNB) genes<jats:italic> (TRIOBP, LHFPL5, CDH23, PCDH15, <\/jats:italic>and<jats:italic> MYO7A)<\/jats:italic>. The custom capture panel in our study provided an efficient and comprehensive diagnosis for known deafness genes in small families.<\/jats:p>","DOI":"10.1155\/2018\/3103986","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T18:30:44Z","timestamp":1516041044000},"page":"1-7","source":"Crossref","is-referenced-by-count":16,"title":["Targeted Next-Generation Sequencing of a Deafness Gene Panel (MiamiOtoGenes) Analysis in Families Unsuitable for Linkage Analysis"],"prefix":"10.1155","volume":"2018","author":[{"given":"Haiqiong","family":"Shang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naeimeh","family":"Tayebi","sequence":"additional","affiliation":[{"name":"Applied Physiology Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kolsoum","family":"Saeidi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran"},{"name":"Department of Medical Genetics, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afsaneh","family":"Sahebalzamani","sequence":"additional","affiliation":[{"name":"Paediatric and Genetic Counselling Center, Kerman Welfare Organization, Kerman, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Blanton","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA"},{"name":"John P. 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