{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:58Z","timestamp":1787017738686,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T00:00:00Z","timestamp":1533686400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2018,8,8]]},"abstract":"<jats:p>\n                    <jats:italic>Background\/Aims.<\/jats:italic>\n                    In early endoscopic retrograde cholangiopancreatography (ERCP) for acute cholangitis due to choledocholithiasis, it is unclear that single-session stone removal can be safely performed. We examined the efficacy and safety of early single-session stone removal for mild-to-moderate acute cholangitis associated with choledocholithiasis.\n                    <jats:italic>Methods.<\/jats:italic>\n                    Among patients with mild-to-moderate acute cholangitis associated with choledocholithiasis who underwent early ERCP (n = 167), we retrospectively compared the removal group (patients who underwent single-session stone removal; n = 78) with the drainage group (patients who underwent biliary drainage alone; n = 89) and examined the effectiveness and safety of single-session stone removal by early ERCP.\n                    <jats:italic>Results.<\/jats:italic>\n                    The patients in the removal group had significantly fewer and smaller stones compared with those in the drainage group. The single-session complete stone removal rate was 85.9% in the removal group. The complication rate in early ERCP was 11.5% in the removal group and 10.1% in the drainage group, with no significant difference (P = 0.963). On comparing patients who underwent early endoscopic sphincterotomy (EST) with those who underwent elective EST after cholangitis had improved, the post-EST bleeding rates were 6.8% and 2.7%, respectively, with no significant difference (P = 0.600). The mean duration of hospitalization was 11.9 days for the removal group and 19.9 days for the drainage group, indicating a shorter stay for the removal group (P &lt; 0.001). In multiple linear regression analysis, stone removal in early ERCP, number of stones, and C-reactive protein level were significant predictors of hospitalization period.\n                    <jats:italic>Conclusions.<\/jats:italic>\n                    Single-session stone removal for mild-to-moderate acute cholangitis can be safely performed. It is useful from the perspective of shorter hospital stay.\n                  <\/jats:p>","DOI":"10.1155\/2018\/3145107","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T19:30:49Z","timestamp":1533756649000},"page":"1-7","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy and Safety of Single-Session Endoscopic Stone Removal for Acute Cholangitis Associated with Choledocholithiasis"],"prefix":"10.1155","volume":"2018","author":[{"given":"Junya","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-030X","authenticated-orcid":true,"given":"Kazunari","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomi","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigo","family":"Suetani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Michikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2116-4958","authenticated-orcid":true,"given":"Shinjiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and General Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00534-012-0566-y","volume":"20","year":"2013","journal-title":"Journal of Hepato-Biliary-Pancreatic Surgery"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-012-0569-8"},{"key":"3","first-page":"47","volume":"20","journal-title":"Journal of Hepato-Biliary-Pancreatic Surgery"},{"key":"4","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s00534-012-0537-3","volume":"19","year":"2012","journal-title":"Journal of Hepato-Biliary-Pancreatic 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