{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:21:01Z","timestamp":1779236461090,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["SALUD-2009-C02-126699"],"award-info":[{"award-number":["SALUD-2009-C02-126699"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["SALUD-2009-126731"],"award-info":[{"award-number":["SALUD-2009-126731"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["SALUD-2009-C02-126699"],"award-info":[{"award-number":["SALUD-2009-C02-126699"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["SALUD-2009-126731"],"award-info":[{"award-number":["SALUD-2009-126731"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2018]]},"abstract":"Background<\/jats:italic>. The influenza A H1N1\/09 pandemic infected a small number of exposed individuals, which suggests the involvement of genetic factors. There are scarce data available on classical HLA class I association with the influenza A H1N1\/09 pandemic. Methods<\/jats:italic>. We analyzed the frequency of classical HLA class I alleles and haplotypes in A H1N1\/09 influenza in a case-control study including 138 influenza patients (INF-P) and 225 asymptomatic healthy contacts (INF-C) simultaneously recruited. HLA class I typing was performed by high-resolution sequence-based typing method. Results<\/jats:italic>. Our analysis revealed higher frequency of C\u2217<\/mml:mo><\/mml:math>07:02:01, B\u2217<\/mml:mo><\/mml:math>39:06:02, C\u2217<\/mml:mo><\/mml:math>03:02:01, B\u2217<\/mml:mo><\/mml:math>44:03:01, B\u2217<\/mml:mo><\/mml:math>51:01:05, and B\u2217<\/mml:mo><\/mml:math>73:01 (p<\/mml:mi><<\/mml:mo>0.05<\/mml:mn><\/mml:math>; OR\u2009=\u20091.84\u20139.98) and of two haplotypes\u2014A\u2217<\/mml:mo><\/mml:math>68:01:02-C\u2217<\/mml:mo><\/mml:math>07:02:01 (p<\/mml:mi>=<\/mml:mo>1.05<\/mml:mn>E<\/mml:mi>\u2212<\/mml:mo>05<\/mml:mn><\/mml:math>; OR\u2009=\u200923.99) and B\u2217<\/mml:mo><\/mml:math>35:01:01-C\u2217<\/mml:mo><\/mml:math>07:02.01 (p<\/mml:mi>=<\/mml:mo>4.15<\/mml:mn>E<\/mml:mi>\u2212<\/mml:mo>04<\/mml:mn><\/mml:math>, OR\u2009=\u20092.15)\u2014in A H1N1\/09 influenza subjects. A\u2217<\/mml:mo><\/mml:math>68:01:01 was exclusively present only in the INF-P group (5\/138). A decrease in the frequency of C\u2217<\/mml:mo><\/mml:math>03:03:01, A\u2217<\/mml:mo><\/mml:math>11:01:01, B\u2217<\/mml:mo><\/mml:math>39:01:01, A\u2217<\/mml:mo><\/mml:math>24:02:01, C\u2217<\/mml:mo><\/mml:math>03:04:01, B\u2217<\/mml:mo><\/mml:math>51:01:01, and C\u2217<\/mml:mo><\/mml:math>07:01:01 (p<\/mml:mi><<\/mml:mo>0.05<\/mml:mn><\/mml:math>; OR\u2009=\u20090.12\u20130.52) and of haplotypes A\u2217<\/mml:mo><\/mml:math>02:01:01-B\u2217<\/mml:mo><\/mml:math>35:01:01-C\u2217<\/mml:mo><\/mml:math>04:01:01, A\u2217<\/mml:mo><\/mml:math>24:02:01-B\u2217<\/mml:mo><\/mml:math>35:01:01, B\u2217<\/mml:mo><\/mml:math>39:01:01-C\u2217<\/mml:mo><\/mml:math>07:02:01, and B\u2217<\/mml:mo><\/mml:math>40:02:01-C\u2217<\/mml:mo><\/mml:math>03:04:01 (p<\/mml:mi><<\/mml:mo>0.05<\/mml:mn><\/mml:math>; OR\u2009=\u20090.08\u20130.22) were observed in INF-P group. Conclusion<\/jats:italic>. Selective classical HLA class I allele and haplotype combinations predispose individuals towards susceptibility or protection against the influenza A H1N1\/09 pandemic. This work has significant implications for accessing population transmission risk for A H1N1\/09 or a similar strain breakout in the future.<\/jats:p>","DOI":"10.1155\/2018\/3174868","type":"journal-article","created":{"date-parts":[[2018,2,25]],"date-time":"2018-02-25T18:31:07Z","timestamp":1519583467000},"page":"1-12","source":"Crossref","is-referenced-by-count":26,"title":["An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6877-8124","authenticated-orcid":true,"given":"Ramc\u00e9s","family":"Falf\u00e1n-Valencia","sequence":"first","affiliation":[{"name":"HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas, 14080 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Narayanankutty","sequence":"additional","affiliation":[{"name":"HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas, 14080 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan M.","family":"Res\u00e9ndiz-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas, 14080 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6876-1012","authenticated-orcid":true,"given":"Gloria","family":"P\u00e9rez-Rubio","sequence":"additional","affiliation":[{"name":"HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas, 14080 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2673-5753","authenticated-orcid":true,"given":"Alejandra","family":"Ram\u00edrez-Venegas","sequence":"additional","affiliation":[{"name":"Tobacco Smoking and COPD Research Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas, 14080 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karol J.","family":"Nava-Quiroz","sequence":"additional","affiliation":[{"name":"HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas, 14080 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora E.","family":"Bautista-F\u00e9lix","sequence":"additional","affiliation":[{"name":"Tobacco Smoking and COPD Research Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas, 14080 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7916-5163","authenticated-orcid":true,"given":"Gilberto","family":"Vargas-Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Molecular Biology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, 14080 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel D. 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