{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:59:56Z","timestamp":1773410396704,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32 CA151022"],"award-info":[{"award-number":["T32 CA151022"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01EB013427"],"award-info":[{"award-number":["R01EB013427"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P41EB013598"],"award-info":[{"award-number":["P41EB013598"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["2017R1C1B5018396"],"award-info":[{"award-number":["2017R1C1B5018396"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CRI18019-1"],"award-info":[{"award-number":["CRI18019-1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CRI18094-2"],"award-info":[{"award-number":["CRI18094-2"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001453","name":"American Brain Tumor Association","doi-asserted-by":"publisher","award":["T32 CA151022"],"award-info":[{"award-number":["T32 CA151022"]}],"id":[{"id":"10.13039\/100001453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001453","name":"American Brain Tumor Association","doi-asserted-by":"publisher","award":["R01EB013427"],"award-info":[{"award-number":["R01EB013427"]}],"id":[{"id":"10.13039\/100001453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001453","name":"American Brain Tumor Association","doi-asserted-by":"publisher","award":["P41EB013598"],"award-info":[{"award-number":["P41EB013598"]}],"id":[{"id":"10.13039\/100001453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001453","name":"American Brain Tumor Association","doi-asserted-by":"publisher","award":["2017R1C1B5018396"],"award-info":[{"award-number":["2017R1C1B5018396"]}],"id":[{"id":"10.13039\/100001453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001453","name":"American Brain Tumor Association","doi-asserted-by":"publisher","award":["CRI18019-1"],"award-info":[{"award-number":["CRI18019-1"]}],"id":[{"id":"10.13039\/100001453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001453","name":"American Brain Tumor Association","doi-asserted-by":"publisher","award":["CRI18094-2"],"award-info":[{"award-number":["CRI18094-2"]}],"id":[{"id":"10.13039\/100001453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Evaluation and Allocation Committee","award":["T32 CA151022"],"award-info":[{"award-number":["T32 CA151022"]}]},{"name":"Research Evaluation and Allocation Committee","award":["R01EB013427"],"award-info":[{"award-number":["R01EB013427"]}]},{"name":"Research Evaluation and Allocation Committee","award":["P41EB013598"],"award-info":[{"award-number":["P41EB013598"]}]},{"name":"Research Evaluation and Allocation Committee","award":["2017R1C1B5018396"],"award-info":[{"award-number":["2017R1C1B5018396"]}]},{"name":"Research Evaluation and Allocation Committee","award":["CRI18019-1"],"award-info":[{"award-number":["CRI18019-1"]}]},{"name":"Research Evaluation and Allocation Committee","award":["CRI18094-2"],"award-info":[{"award-number":["CRI18094-2"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 CA151022"],"award-info":[{"award-number":["T32 CA151022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB013427"],"award-info":[{"award-number":["R01EB013427"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41EB013598"],"award-info":[{"award-number":["P41EB013598"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2017R1C1B5018396"],"award-info":[{"award-number":["2017R1C1B5018396"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CRI18019-1"],"award-info":[{"award-number":["CRI18019-1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CRI18094-2"],"award-info":[{"award-number":["CRI18094-2"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 CA151022"],"award-info":[{"award-number":["T32 CA151022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB013427"],"award-info":[{"award-number":["R01EB013427"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41EB013598"],"award-info":[{"award-number":["P41EB013598"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2017R1C1B5018396"],"award-info":[{"award-number":["2017R1C1B5018396"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CRI18019-1"],"award-info":[{"award-number":["CRI18019-1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CRI18094-2"],"award-info":[{"award-number":["CRI18094-2"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["T32 CA151022"],"award-info":[{"award-number":["T32 CA151022"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["R01EB013427"],"award-info":[{"award-number":["R01EB013427"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["P41EB013598"],"award-info":[{"award-number":["P41EB013598"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1C1B5018396"],"award-info":[{"award-number":["2017R1C1B5018396"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["CRI18019-1"],"award-info":[{"award-number":["CRI18019-1"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["CRI18094-2"],"award-info":[{"award-number":["CRI18094-2"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["T32 CA151022"],"award-info":[{"award-number":["T32 CA151022"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["R01EB013427"],"award-info":[{"award-number":["R01EB013427"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["P41EB013598"],"award-info":[{"award-number":["P41EB013598"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2017R1C1B5018396"],"award-info":[{"award-number":["2017R1C1B5018396"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["CRI18019-1"],"award-info":[{"award-number":["CRI18019-1"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["CRI18094-2"],"award-info":[{"award-number":["CRI18094-2"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["T32 CA151022"],"award-info":[{"award-number":["T32 CA151022"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["R01EB013427"],"award-info":[{"award-number":["R01EB013427"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["P41EB013598"],"award-info":[{"award-number":["P41EB013598"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["2017R1C1B5018396"],"award-info":[{"award-number":["2017R1C1B5018396"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["CRI18019-1"],"award-info":[{"award-number":["CRI18019-1"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["CRI18094-2"],"award-info":[{"award-number":["CRI18094-2"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["T32 CA151022"],"award-info":[{"award-number":["T32 CA151022"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["R01EB013427"],"award-info":[{"award-number":["R01EB013427"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["P41EB013598"],"award-info":[{"award-number":["P41EB013598"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["2017R1C1B5018396"],"award-info":[{"award-number":["2017R1C1B5018396"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["CRI18019-1"],"award-info":[{"award-number":["CRI18019-1"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["CRI18094-2"],"award-info":[{"award-number":["CRI18094-2"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2018,7,30]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. The purpose of this study was to demonstrate the feasibility of using hyperpolarized carbon-13 (<jats:sup>13<\/jats:sup>C) metabolic imaging with [1-<jats:sup>13<\/jats:sup>C]-labeled pyruvate for evaluating real-time <jats:italic>in vivo<\/jats:italic> metabolism of orthotopic diffuse intrinsic pontine glioma (DIPG) xenografts. <jats:italic>Materials and Methods<\/jats:italic>. 3D <jats:sup>13<\/jats:sup>C magnetic resonance spectroscopic imaging (MRSI) data were acquired on a 3T scanner from 8 rats that had been implanted with human-derived DIPG cells in the brainstem and 5 healthy controls, following injection of 2.5\u2009mL (100\u2009mM) hyperpolarized [1-<jats:sup>13<\/jats:sup>C]-pyruvate. <jats:italic>Results<\/jats:italic>. Anatomical images from DIPG-bearing rats characteristically exhibited T<jats:sub>2<\/jats:sub>-hyperintensity throughout the cerebellum and pons that was not accompanied by contrast enhancement. Evaluation of real-time <jats:italic>in vivo<\/jats:italic><jats:sup>13<\/jats:sup>C spectroscopic data revealed ratios of lactate-to-pyruvate (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:mrow><\/mml:math>), lactate-to-total carbon (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:mrow><\/mml:math>), and normalized lactate (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:mrow><\/mml:math>) that were significantly higher in T<jats:sub>2<\/jats:sub> lesions harboring tumor relative to corresponding values of healthy normal brain. Elevated levels of lactate in lesions demonstrated a distinct metabolic profile that was associated with infiltrative, viable tumor recapitulating the histopathology of pediatric DIPG. <jats:italic>Conclusions<\/jats:italic>. Results from this study characterized pyruvate and lactate metabolism in orthotopic DIPG xenografts and suggest that hyperpolarized <jats:sup>13<\/jats:sup>C MRSI may serve as a noninvasive imaging technique for <jats:italic>in vivo<\/jats:italic> monitoring of biochemical processes in patients with DIPG.<\/jats:p>","DOI":"10.1155\/2018\/3215658","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T19:31:12Z","timestamp":1532979072000},"page":"1-6","source":"Crossref","is-referenced-by-count":12,"title":["Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging"],"prefix":"10.1155","volume":"2018","author":[{"given":"Adam W.","family":"Autry","sequence":"first","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rintaro","family":"Hashizume","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. David","family":"James","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peder E. Z.","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel B.","family":"Vigneron","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6022-8363","authenticated-orcid":true,"given":"Ilwoo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology, Chonnam National University Medical School, Gwangju, Republic of Korea"},{"name":"Department of Radiology, Chonnam National University Hospital, Gwangju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noq205"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.06.033"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-007-9473-5"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.176.2.1760289"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-006-0191-5"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.a5076"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1733835100"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006070"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-012-0973-6"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nop043"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24434"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1307-x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.43.375"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1218-2"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1126\/science.123.3191.309"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2289"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-09-2251"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27077"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.09.027"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-2007-042"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.01.032"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nor038"}],"container-title":["Contrast Media &amp; Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmi\/2018\/3215658.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmi\/2018\/3215658.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmi\/2018\/3215658.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T19:31:36Z","timestamp":1534188696000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmi\/2018\/3215658\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,30]]},"references-count":22,"alternative-id":["3215658","3215658"],"URL":"https:\/\/doi.org\/10.1155\/2018\/3215658","relation":{},"ISSN":["1555-4309","1555-4317"],"issn-type":[{"value":"1555-4309","type":"print"},{"value":"1555-4317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,30]]}}}