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In the activation of HSC, the TGF\u2010<jats:italic>\u03b2<\/jats:italic>1 plays a key role that can promote the occurrence of hepatic fibrosis by combining with Smad proteins. Astragaloside is the main active component extracted from <jats:italic>Radix Astragali<\/jats:italic> that has the effect of antioxidation and hepatoprotection. In the present study, we investigated the mechanism of astragalosides inhibiting hepatic fibrosis <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. <jats:italic>In vitro<\/jats:italic>, astragalosides inhibited the activation of HSC and regulated the expression of MMP\u20102 and TIMP\u20102 and reduced the formation of collagen fibers. <jats:italic>In vivo<\/jats:italic>, administration of astragalosides decreased the serum ALT, AST, and TBiL in rats by reducing oxidative stress. Astragalosides also attenuated hepatic fibrosis by reducing the concentration of hydroxyproline and inhibiting the formation of collagen fibers. The expressions of TGF\u2010<jats:italic>\u03b2<\/jats:italic>1, T<jats:italic>\u03b2<\/jats:italic>R\u2010I, p\u2010Smad 2, and p\u2010Smad 3 were downregulated after astragalosides treatments, while Smad 7 was upregulated compared to the control group. The results indicated that the effect of astragaloside on hepatic fibrosis was related to the inhibition of HSC activation and the modulation of the TGF\u2010<jats:italic>\u03b2<\/jats:italic>1\/Smad signaling pathway.<\/jats:p>","DOI":"10.1155\/2018\/3231647","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T23:31:02Z","timestamp":1525131062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Astragaloside Inhibits Hepatic Fibrosis by Modulation of TGF\u2010<i>\u03b2<\/i>1\/Smad Signaling Pathway"],"prefix":"10.1155","volume":"2018","author":[{"given":"Xingxing","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7822-3114","authenticated-orcid":false,"given":"Yali","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,30]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2016.11.004"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.03.002"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00230.2013"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1756283x11413002"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-306842"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.003"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1190-4"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.01.004"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.4.2247"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1273rev"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.07.025"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X0600448X"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1001-1978.2011.11.031"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.01.008"},{"key":"e_1_2_8_15_2","first-page":"447","article-title":"Effects of total astragalosides on hepatoma cells apoptosis and wtp53 expression","volume":"17","author":"Yang Y.","year":"2001","journal-title":"Chinese Pharmacological Bulletin"},{"key":"e_1_2_8_16_2","first-page":"892","article-title":"Effect of astragalosides on proliferation and collagen production of hepatic stellate cells in vitro","volume":"19","author":"Wu Q.","year":"2003","journal-title":"Chinese Pharmacological Bulletin"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.5.1105"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.07002.x"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200524282"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1246-y"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2277"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05345.x"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2016.35"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2015.58"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm0205705"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(02)00225-9"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2012.02.015"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04797.x"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-171"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.09.031"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-011-0116-0"},{"key":"e_1_2_8_32_2","first-page":"71","article-title":"The role of antioxidant vitamins (C and E), selenium and Nigella sativa in the prevention of liver fibrosis and cirrhosis in rabbits: new hopes","volume":"108","author":"Turkdogan M. 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