{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:17:07Z","timestamp":1760120227988,"version":"3.41.2"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"vor","delay-in-days":198,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Research and Development Program of Shaanxi Province of China","award":["2017ZDXM-SF-008"],"award-info":[{"award-number":["2017ZDXM-SF-008"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To evaluate the clinical efficacy and safety of Compound Danshen Dripping Pill (CDDP) and Isosorbide Mononitrate (ISMN) in the treatment of unstable angina pectoris (UAP) in the elderly. <jats:italic>Materials and Methods<\/jats:italic>. CNKI, Wanfang, VIP, CBM, and PubMed databases were searched for appropriate articles without language limitations on keywords. RevMan 5.3 software was used to perform the meta\u2010analysis. <jats:italic>Results<\/jats:italic>. This analysis compared CDDP with ISMN of 21 randomized controlled trials (RCTs) that involved a total of 2356 patients with UAP. When the treatment lasted for four weeks, the clinical effective rate was OR = 3.97, 95% CI = 2.97, 5.30, and <jats:italic>P<\/jats:italic> &lt; 0.00001, the ECG efficiency was OR = 3.43, 95% CI = 2.13, 5.53, and <jats:italic>P<\/jats:italic> &lt; 0.00001, and incidence of adverse reactions was OR = 0.73, 95% CI = 0.52, 1.04, and <jats:italic>P<\/jats:italic> = 0.08 &gt; 0.05. When the treatment lasted for eight weeks, clinical efficiency rate was OR = 4.22, 95% CI = 2.37, 3.79, and <jats:italic>P<\/jats:italic> &lt; 0.00001, incidence of adverse reactions was OR = 0.58, 95% CI = 0.26, 1.27, and <jats:italic>P<\/jats:italic> = 0.17 &gt; 0.05, whole blood low\u2010cut blood viscosity was SMD = \u20100.61 and 95% CI \u20101.60, 0.38, whole blood high\u2010cut blood viscosity was SMD = \u20100.38 and 95% CI \u20100.97, 0.21, and blood cells specific volume was SMD = \u20100.80 and 95% CI \u20102.61, 1.01. <jats:italic>Conclusion<\/jats:italic>. Based on this meta\u2010analysis, the CDDP was superior to ISMN with UAP in the elderly. However, there is still a need to further verify the clinical efficacy and safety of CDDP with more strictly designed RCTs with large sample and multiple centers in the future.<\/jats:p>","DOI":"10.1155\/2018\/3429151","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T23:58:12Z","timestamp":1531958292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Relationship between Compound Danshen Dripping Pills with Isosorbide Mononitrate in the Treatment of Elderly Patients with Unstable Angina Pectoris"],"prefix":"10.1155","volume":"2018","author":[{"given":"Yulin","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junbo","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Tai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunli","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangxue","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1178-5504","authenticated-orcid":false,"given":"Yajun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,18]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010142"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-017-2424-x"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1110"},{"key":"e_1_2_11_4_2","first-page":"69","article-title":"Progress in the treatment of unstable angina","volume":"02","author":"Hui J. 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