{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:00:47Z","timestamp":1784127647041,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. The MIC (MHC class I chain-related) genes are a group of nonclassical MHC genes, located in the MHC class 1 region of chromosome 6. The aim of the present study was to find the prevalence of MHC class 1 chain-related (MICA) alloantibodies in patients undergoing live-related donor renal transplantation and its role in short-term graft survival. The role of blood transfusion in the formation of these antibodies was also studied. <jats:italic>Materials and Methods<\/jats:italic>. Pretransplant samples of patients undergoing renal allograft transplantation were tested for anti-MICA antibodies. Association of various demographics, HLA-A\u2009+\u2009B\u2009+\u2009DRB1 mismatches, anti-HLA antibody screen, and anti-MICA antibodies was assessed using Pearson\u2019s chi-square test. <jats:italic>Results<\/jats:italic>. Out of 646 serum samples, 94 (14.6%) were positive and 552 (85.4%) were negative for anti-MICA antibodies. Patients with anti-MICA antibody had a graft survival 89.3% as compared to 94.7% in patients without anti-MICA antibody (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). The hazard ratio for all patients was 3.0701 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Out of the 340 patients with no HLA antibodies, the presence of anti-MICA antibodies without any HLA antibodies (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>43<\/mml:mn><\/mml:math>) was associated with poor outcome in the patients (hazard ratio of 2.768, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). The presence of MICA antibodies with HLA antibodies did not decrease the graft survival (hazards ratio of 1.3750, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). <jats:italic>Conclusion<\/jats:italic>. Preformed MICA antibodies independently increase the risk of kidney rejection and therefore recommend that guidelines should be formed for mandatory testing of these antibodies prior to renal transplant.<\/jats:p>","DOI":"10.1155\/2018\/3434050","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T20:15:15Z","timestamp":1522959315000},"page":"1-7","source":"Crossref","is-referenced-by-count":10,"title":["Role of Anti-MICA Antibodies in Graft Survival of Renal Transplant Recipients of India"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2894-4989","authenticated-orcid":true,"given":"Mohit","family":"Chowdhry","sequence":"first","affiliation":[{"name":"Transplant Immunology, Sarita Vihar, Delhi Mathura Road, Molecular Biology and Transfusion Medicine Apollo Hospitals, New Delhi 110076, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. N.","family":"Makroo","sequence":"additional","affiliation":[{"name":"Transplant Immunology, Sarita Vihar, Delhi Mathura Road, Molecular Biology and Transfusion Medicine Apollo Hospitals, New Delhi 110076, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandhata","family":"Singh","sequence":"additional","affiliation":[{"name":"Transplant Immunology, Sarita Vihar, Delhi Mathura Road, Molecular Biology and Transfusion Medicine Apollo Hospitals, New Delhi 110076, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Transplant Immunology, Sarita Vihar, Delhi Mathura Road, Molecular Biology and Transfusion Medicine Apollo Hospitals, New Delhi 110076, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogita","family":"Thakur","sequence":"additional","affiliation":[{"name":"Transplant Immunology, Sarita Vihar, Delhi Mathura Road, Molecular Biology and Transfusion Medicine Apollo Hospitals, New Delhi 110076, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Sharma","sequence":"additional","affiliation":[{"name":"Transplant Immunology, Sarita Vihar, Delhi Mathura Road, Molecular Biology and Transfusion Medicine Apollo Hospitals, New Delhi 110076, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.14.6259"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5428.727"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(00)00162-2"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.02.017"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067160"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181e228f7"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2011.12.002"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02159.x"},{"key":"10","first-page":"449","volume-title":"Deduction of the fraction of immunologic and non-immunologic failure in cadaver donor transplants","year":"2003"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66458-6"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/ndtplus\/sfp178"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181bbbe4c"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31818bd790"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e328355f12b"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(01)00349-4"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2015.11.023"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2017.06.224"},{"key":"19","first-page":"265","year":"2006","journal-title":"Clinical Transplants"},{"issue":"14","key":"20","first-page":"2127","volume":"124","year":"2011","journal-title":"Chinese Medical Journal"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv308"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200207270-00019"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01016.x"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.06.002"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01407.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182943506"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2007.01.006"},{"key":"28","year":"2007"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01644.x"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31827a19cc"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2018\/3434050.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2018\/3434050.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2018\/3434050.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T20:15:15Z","timestamp":1522959315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jir\/2018\/3434050\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":29,"alternative-id":["3434050","3434050"],"URL":"https:\/\/doi.org\/10.1155\/2018\/3434050","relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}