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Genetic polymorphisms in molecular pathways involving G protein-coupled receptor signalling, the Akt\/PI3K cascade, the mitotic cell cycle, and immune response have been identified in association with the development of trachomatous scarring, an ocular form of chlamydia-related fibrotic pathology. In this case-control study, we performed genome-wide association and pathways-based analysis in a sample of 71 Dutch women who attended an STI clinic who were seropositive for\n                    <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                    antibodies and 169 high-risk Dutch women who sought similar health services but who were seronegative. We identified two regions of within-gene SNP association with\n                    <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                    serological response and found that GPCR signalling and cell cycle pathways were also associated with the trait. These pathway-level associations appear to be common to immunological sequelae of chlamydial infections in both ocular and urogenital tropisms. These pathways may be central mediators of human refractoriness to chlamydial diseases.\n                  <\/jats:p>","DOI":"10.1155\/2018\/3434101","type":"journal-article","created":{"date-parts":[[2018,6,3]],"date-time":"2018-06-03T19:32:18Z","timestamp":1528054338000},"page":"1-9","source":"Crossref","is-referenced-by-count":2,"title":["Pathway-Wide Genetic Risks in Chlamydial Infections Overlap between Tissue Tropisms: A Genome-Wide Association Scan"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1064-5980","authenticated-orcid":true,"given":"Chrissy H.","family":"Roberts","sequence":"first","affiliation":[{"name":"Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2092-0002","authenticated-orcid":true,"given":"Sander","family":"Ouburg","sequence":"additional","affiliation":[{"name":"Institute for Public Health Genomics, Department of Genetics and Cell Biology, School for Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D.","family":"Preston","sequence":"additional","affiliation":[{"name":"National Institute for Biological Standards and Controls, Potters Bar, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry J. 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