{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:29:35Z","timestamp":1740169775887,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010849","name":"Health and Family Planning Commission of Wuhan Municipality","doi-asserted-by":"crossref","award":["WX17B02","WJ2017M183"],"award-info":[{"award-number":["WX17B02","WJ2017M183"]}],"id":[{"id":"10.13039\/501100010849","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010846","name":"Health and Family Planning Commission of Hubei Province","doi-asserted-by":"crossref","award":["WX17B02","WJ2017M183"],"award-info":[{"award-number":["WX17B02","WJ2017M183"]}],"id":[{"id":"10.13039\/501100010846","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>The aim of this study was to investigate whether osteopontin<jats:italic>(OPN)<\/jats:italic>variants are associated with susceptibility to ankylosing spondylitis (AS) in a Chinese population. Polymorphisms at the 9175th position in exon 7 of<jats:italic>OPN<\/jats:italic>and rs17524488 were genotyped using direct sequencing in 186 unrelated AS patients and 188 ethnically matched healthy controls. Serum concentration of OPN was measured by enzyme-linked immunosorbent assay (ELISA) in all participants. AS patients displayed significantly higher OPN serum levels than the controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">001<\/mml:mn><\/mml:math>). A heterozygous, novel 9175 T&gt;A in exon 7 of the<jats:italic>OPN<\/jats:italic>gene was found in this study. In healthy controls, subjects carrying the rs17524488 G\/G genotype of the<jats:italic>OPN<\/jats:italic>display significantly higher OPN serum levels than the GG\/GG genotype (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). Plasma OPN level is implicated as an early diagnostic marker of AS. The novel 9175th- (exon 7) position polymorphism of<jats:italic>OPN<\/jats:italic>and rs17524488 were related to susceptibility to AS in a Chinese population, the rs17524488 G\/G genotype may be involved in the pathogenesis of AS, and the precise molecular mechanism underlying the influence of<jats:italic>OPN<\/jats:italic>polymorphisms on the development of AS remains to be determined in the further prospective studies.<\/jats:p>","DOI":"10.1155\/2018\/3458439","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T23:35:35Z","timestamp":1516318535000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Polymorphisms in the Osteopontin Are Associated with Susceptibility to Ankylosing Spondylitis in a Han Chinese Population"],"prefix":"10.1155","volume":"2018","author":[{"given":"Juyi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pain, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2119-7570","authenticated-orcid":true,"given":"Aiping","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 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