{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:15:28Z","timestamp":1787166928662,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T00:00:00Z","timestamp":1532476800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,7,25]]},"abstract":"\n Pruritus is an important symptom frequently accompanying various inflammatory skin conditions. Some recent data have indicated that it may also be associated with autoimmune connective tissue diseases, including systemic sclerosis and dermatomyositis; however, studies on the prevalence and clinical characteristics of pruritus in CLE are limited. We have performed a multinational, prospective, cross-sectional study in order to assess the prevalence and intensity of pruritus in adult patients suffering from various subtypes of CLE. After developing a questionnaire assessing various aspects of pruritus, we have surveyed 567 patients with cutaneous involvement during the course of LE regarding the presence and intensity of pruritus. Pruritus was present in 425 of all patients (75.0%) and was most frequently reported by subjects with acute CLE (82.1%), followed by chronic CLE (78.8%), subacute CLE (65.9%), and intermittent CLE (55.6%) (p<0.001). Based on the Numerical Rating Scale, the severity of itch was mild, moderate, and severe in 264 (62.1%), 98 (23.1%), and 63 (14.8%) patients, respectively. The highest mean pruritus intensity was reported by subjects with hypertrophic LE (\n \n 5.1<\/mml:mn>\n \u00b1<\/mml:mo>\n 3.0<\/mml:mn>\n <\/mml:math>\n points) followed by generalized discoid LE (\n \n 3.6<\/mml:mn>\n \u00b1<\/mml:mo>\n 3.0<\/mml:mn>\n <\/mml:math>\n points), subacute CLE (\n \n 3.0<\/mml:mn>\n \u00b1<\/mml:mo>\n 3.0<\/mml:mn>\n <\/mml:math>\n points), chilblain LE (\n \n 3.0<\/mml:mn>\n \u00b1<\/mml:mo>\n 1.0<\/mml:mn>\n <\/mml:math>\n points), localized discoid LE (\n \n 2.6<\/mml:mn>\n \u00b1<\/mml:mo>\n 2.0<\/mml:mn>\n <\/mml:math>\n points), intermittent CLE (\n \n 2.6<\/mml:mn>\n \u00b1<\/mml:mo>\n 3.0<\/mml:mn>\n <\/mml:math>\n points), acute CLE (\n \n 2.5<\/mml:mn>\n \u00b1<\/mml:mo>\n 1.2<\/mml:mn>\n <\/mml:math>\n points), and lupus erythematosus profundus (\n \n 1.9<\/mml:mn>\n \u00b1<\/mml:mo>\n 2.7<\/mml:mn>\n <\/mml:math>\n points). In conclusion, pruritus is a frequent phenomenon in CLE; however, in most patients it is of mild severity. Further studies are needed to better characterize its clinical characteristics and influence on patients\u2019 well-being.\n <\/jats:p>","DOI":"10.1155\/2018\/3491798","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T19:31:10Z","timestamp":1532547070000},"page":"1-5","source":"Crossref","is-referenced-by-count":16,"title":["Prevalence of Pruritus in Cutaneous Lupus Erythematosus: Brief Report of a Multicenter, Multinational Cross-Sectional Study"],"prefix":"10.1155","volume":"2018","author":[{"given":"Dominik","family":"Samotij","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Rzeszow, Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Szcz\u0119ch","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Rzeszow, Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn J.","family":"Kushner","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania and Corporal Michael J. Crescenz VAMC, Philadelphia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Rafiqul","family":"Mowla","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chittagong Medical College, Chittagong, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Da\u0144czak-Pazdrowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-4433","authenticated-orcid":true,"given":"Emiliano","family":"Antiga","sequence":"additional","affiliation":[{"name":"Department of Surgery and Translational Medicine, Section of Dermatology, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Chasset","sequence":"additional","affiliation":[{"name":"Sorbonne University, Department of Dermatology and Allergology, Tenon Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukumi","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Wakayama Medical University, Wakayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Yoshida-gun, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Hashizume","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shimada Municipal Hospital, Shimada, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aminul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chittagong Medical College, Chittagong, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaharu","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Wakayama Medical University, Wakayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Lesiak","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Pediatric Dermatology and Oncology Clinic, Medical University of Lodz, \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Pola\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8088-7059","authenticated-orcid":true,"given":"Laurent","family":"Misery","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital of Brest, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0766-6342","authenticated-orcid":true,"given":"Jacek C.","family":"Szepietowski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zygmunt","family":"Adamski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria P.","family":"Werth","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania and Corporal Michael J. Crescenz VAMC, Philadelphia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5573-1754","authenticated-orcid":true,"given":"Adam","family":"Reich","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Rzeszow, Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1177\/096120339700600203"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/b137847"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0305"},{"key":"4","first-page":"91","volume-title":"The prevalence and intensity of itch among dermatological patients in 13 European countries. 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