{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T14:16:23Z","timestamp":1773497783252,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"Aim<\/jats:italic>. The aim of this study was to evaluate short-term patency of the new prosthetic graft and its structural changes after explantation. Methods<\/jats:italic>. The study team developed a three-layer conduit composed of a scaffold made from polyester coated with collagen from the inner and outer side with an internal diameter of 6\u2009mm. The conduit was implanted as a bilateral bypass to the carotid artery in 7 sheep and stenosis was created in selected animals. After a period of 161 days, the explants were evaluated as gross and microscopic specimens. Results<\/jats:italic>. The initial flow rate (median \u00b1 IQR) in grafts with and without artificial stenosis was 120<\/mml:mn>\u00b1<\/mml:mo>79<\/mml:mn><\/mml:math>\u2009ml\/min and 255<\/mml:mn>\u00b1<\/mml:mo>255<\/mml:mn><\/mml:math>\u2009ml\/min, respectively. Graft occlusion occurred after 99 days in one of 13 conduits (patency rate: 92%). Wall-adherent thrombi occurred only in sharp curvatures in two grafts. Microscopic evaluation showed good engraftment and preserved structure in seven conduits; inflammatory changes with foci of bleeding, necrosis, and disintegration in four conduits; and narrowing of the graft due to thickening of the wall with multifocal separation of the outer layer in two conduits. Conclusions<\/jats:italic>. This study demonstrates good short-term patency rates of a newly designed three-layer vascular graft even in low-flow conditions in a sheep model.<\/jats:p>","DOI":"10.1155\/2018\/3519596","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T18:30:53Z","timestamp":1519756253000},"page":"1-7","source":"Crossref","is-referenced-by-count":17,"title":["In Vivo Evaluation of Short-Term Performance of New Three-Layer Collagen-Based Vascular Graft Designed for Low-Flow Peripheral Vascular Reconstructions"],"prefix":"10.1155","volume":"2018","author":[{"given":"Tomas","family":"Grus","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 128 08 Prague 2, Czech 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