{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:02:21Z","timestamp":1740164541186,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2018,9,25]]},"abstract":"<jats:p>Sarcoidosis is a systemic inflammatory disease characterized by the presence of noncaseating granulomas in different organs. Sarcoidosis associated with monoclonal gammopathy of undetermined significance (MGUS) is a rare finding with only 10 cases reported to date. We describe a 79-year-old male patient who presented with dry mouth for 4 months. Lip biopsy done prior to admission showed nonnecrotizing epithelioid cell granulomas. On admission, laboratory analysis was significant for elevated calcium, decreased parathyroid hormone, increased erythrocyte sedimentation rate, undetectable parathyroid hormone-related peptide (PTHrp), mildly decreased 25-hydroxyvitamin D, elevated 1,25-dihydroxyvitamin D, elevated angiotensin converting enzyme, and positive Bence Jones protein in the urine. Serum protein electrophoresis showed an elevated gamma globulin level at 38% and an IgG monoclonal gammopathy with an M-spike of 1.47. Bone marrow biopsy was consistent with MGUS. The patient showed significant improvement with steroids and was discharged with close follow-up from nephrology and oncology. Salivary gland involvement in patients with sarcoidosis is a rare finding. Our case is a valuable addition to the small number of cases described in the literature supporting an association between plasma cell disorders and sarcoidosis. Larger prospective studies are needed to determine if a true association between the two diseases exists.<\/jats:p>","DOI":"10.1155\/2018\/3790760","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T23:31:23Z","timestamp":1537918283000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Sarcoidosis and Monoclonal Gammopathy of Undetermined Significance (MGUS): A True Association or Just a Coincidence?"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8247-5936","authenticated-orcid":true,"given":"Mohamed","family":"Hassanein","sequence":"first","affiliation":[{"name":"Michigan State University, Clinical Center, 788 Service Road, East Lansing, MI 48824, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8530-0907","authenticated-orcid":true,"given":"Lilit","family":"Karapetyan","sequence":"additional","affiliation":[{"name":"Michigan State University, Clinical Center, 788 Service Road, East Lansing, MI 48824, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afshan","family":"Khan","sequence":"additional","affiliation":[{"name":"Michigan State University, Clinical Center, 788 Service Road, East Lansing, MI 48824, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supratik","family":"Rayamajhi","sequence":"additional","affiliation":[{"name":"Michigan State University, Clinical Center, 788 Service Road, East Lansing, MI 48824, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(12)60235-9"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1475"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1986.199"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-007-0026-8"},{"issue":"9","key":"5","first-page":"342","volume":"98","year":"1992","journal-title":"Medicina Cl\u00ednica"},{"issue":"1","key":"6","first-page":"70","volume":"9","year":"1992","journal-title":"Sarcoidosis"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/bf03044760"},{"issue":"3","key":"8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.5858\/2002-126-0365-MMIAWS","volume":"126","year":"2002","journal-title":"Archives of Pathology & Laboratory Medicine"},{"issue":"12","key":"9","first-page":"809","volume":"148","year":"2009","journal-title":"Harefuah"},{"issue":"2","key":"10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4103\/2231-0770.130346","volume":"4","year":"2014","journal-title":"Avicenna Journal of Medicine"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-016-0072-5"},{"volume":"193","journal-title":"American Journal of Respiratory and Critical Care Medicine","year":"2016","key":"12"},{"key":"13","first-page":"A3385","volume":"195","year":"2017","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"1","key":"14","first-page":"133","volume":"85","year":"2012","journal-title":"Yale Journal of Biology and Medicine"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra071714"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01014.x"},{"issue":"2","key":"17","first-page":"119","volume":"13","year":"2009","journal-title":"Hippokratia"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcs042"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.10.2104046"},{"issue":"2","key":"20","first-page":"108","volume":"31","year":"2014","journal-title":"Sarcoidosis, Vasculitis, and Diffuse Lung Diseases"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2016.12.010"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1148\/rg.306105512"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.035"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.03.010"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.06986.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198108203050804"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(10)60482-5"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1038"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2018\/3790760.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2018\/3790760.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2018\/3790760.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T18:54:47Z","timestamp":1662144887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2018\/3790760\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,25]]},"references-count":28,"alternative-id":["3790760","3790760"],"URL":"https:\/\/doi.org\/10.1155\/2018\/3790760","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"type":"print","value":"2090-6560"},{"type":"electronic","value":"2090-6579"}],"subject":[],"published":{"date-parts":[[2018,9,25]]}}}