{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:32:23Z","timestamp":1773221543072,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Postoperative air leaks remain a major cause of morbidity after lung resection. This study evaluated the effect of a combination of polyglycolic acid (PGA) sheet and alginate gel on pulmonary air leaks in rats. Four pulmonary sealing materials were evaluated in lung injury: fibrin glue, combination of PGA sheet and fibrin glue, alginate gel, and combination of PGA sheet and alginate gel. With the airway pressure maintained at 20\u2009cmH<jats:sub>2<\/jats:sub>O, a 2\u2009mm deep puncture wound was created on the lung surface using a needle. Lowering the airway pressure to 5\u2009cmH<jats:sub>2<\/jats:sub>O, each sealing material was applied. The lowest airway pressure that broke the seal was measured. The seal-breaking pressure in each experimental group was fibrin, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn fontstyle=\"italic\">10<\/mml:mn><mml:mtext>.<\/mml:mtext><mml:mn fontstyle=\"italic\">4<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">6<\/mml:mn><mml:mtext>.<\/mml:mtext><mml:mn fontstyle=\"italic\">8<\/mml:mn><\/mml:math>\u2009cmH<jats:sub>2<\/jats:sub>O; PGA + fibrin, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn fontstyle=\"italic\">13<\/mml:mn><mml:mtext>.<\/mml:mtext><mml:mn fontstyle=\"italic\">5<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">6<\/mml:mn><mml:mtext>.<\/mml:mtext><mml:mn fontstyle=\"italic\">5<\/mml:mn><\/mml:math>\u2009cmH<jats:sub>2<\/jats:sub>O; alginate gel, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn fontstyle=\"italic\">10<\/mml:mn><mml:mtext>.<\/mml:mtext><mml:mn fontstyle=\"italic\">3<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">4<\/mml:mn><mml:mtext>.<\/mml:mtext><mml:mn fontstyle=\"italic\">9<\/mml:mn><\/mml:math>\u2009cmH<jats:sub>2<\/jats:sub>O; and PGA + alginate, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mn fontstyle=\"italic\">35<\/mml:mn><mml:mtext>.<\/mml:mtext><mml:mn fontstyle=\"italic\">8<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">11<\/mml:mn><mml:mtext>.<\/mml:mtext><mml:mn fontstyle=\"italic\">9<\/mml:mn><\/mml:math>\u2009cmH<jats:sub>2<\/jats:sub>O, respectively. The seal-breaking pressure was significantly greater in the PGA + alginate gel group than in the other groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0<\/mml:mn><mml:mtext>.<\/mml:mtext><mml:mn fontstyle=\"italic\">01<\/mml:mn><\/mml:math>). There were no significant differences among the other three groups. Alginate gel combined with a PGA sheet is a promising alternative to fibrin glue as a safe and low-cost material for air leak prevention in pulmonary surgery.<\/jats:p>","DOI":"10.1155\/2018\/3808675","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T18:34:17Z","timestamp":1514918057000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["Reduction of Pulmonary Air Leaks with a Combination of Polyglycolic Acid Sheet and Alginate Gel in Rats"],"prefix":"10.1155","volume":"2018","author":[{"given":"Mari","family":"Matoba","sequence":"first","affiliation":[{"name":"Medical Life System, Faculty of Life and Medical Science, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe, Kyoto 610-0394, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshitaka","family":"Takagi","sequence":"additional","affiliation":[{"name":"Medical Life System, Faculty of Life and Medical Science, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe, Kyoto 610-0394, Japan"},{"name":"Fushimi Okamoto Hospital, 9-50 Kyomachi, Hushimi-Ku, Kyoto, Kyoto 612-8083, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tsujimoto","sequence":"additional","affiliation":[{"name":"Medical Life System, Faculty of Life and Medical Science, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe, Kyoto 610-0394, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Ozamoto","sequence":"additional","affiliation":[{"name":"Kusatsu General Hospital, 1660 Yabase-cho, Kusatsu, Shiga 525-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Ueda","sequence":"additional","affiliation":[{"name":"Kainan Hospital, 396 Minamihonden, Maegasu-cho, Yatomi, Aichi 498-8502, 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