{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:28:38Z","timestamp":1781105318140,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Psychiatry"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Huntington\u2019s disease (HD) is an inherited, progressive, and neurodegenerative neuropsychiatric disorder caused by the expansion of cytosine-adenine-guanine (CAG) trinucleotide in Interested Transcript (IT) 15 gene on chromosome 4. This pathology typically presents in individuals aged between 30 and 50 years and the age of onset is inversely correlated with the length of the CAG repeat expansion. It is characterized by chorea, cognitive deficits, and psychiatric symptoms. Usually the psychiatric disorders precede motor and cognitive impairment, Major Depressive Disorder and anxiety disorders being the most common presentations. We present a clinical case of a 65-year-old woman admitted to our Psychiatric Acute Unit. During the 6 years preceding the admission, the patient had clinical assessments made several times by different specialties that focused only on isolated symptoms, disregarding the syndrome as a whole. In the course of her last admission, the patient was referred to our Neuropsychiatric Team, which made the provisional diagnosis of late-onset Huntington\u2019s disease, later confirmed by genetic testing. This clinical vignette highlights the importance of a multidisciplinary approach to atypical clinical presentations and raises awareness for the relevance of investigating carefully motor symptoms in psychiatric patients.<\/jats:p>","DOI":"10.1155\/2018\/3915657","type":"journal-article","created":{"date-parts":[[2018,2,18]],"date-time":"2018-02-18T18:31:25Z","timestamp":1518978685000},"page":"1-4","source":"Crossref","is-referenced-by-count":2,"title":["Huntington\u2019s Disease in a Patient Misdiagnosed as Conversion Disorder"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4386-0361","authenticated-orcid":true,"given":"Jo\u00e3o Machado","family":"Nogueira","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Mental Health, Set\u00fabal Hospital Center, Rua Camilo Castelo Branco, 2910-446 Set\u00fabal, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2035-0599","authenticated-orcid":true,"given":"Ana Margarida","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Mental Health, Set\u00fabal Hospital Center, Rua Camilo Castelo Branco, 2910-446 Set\u00fabal, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Mendes","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Mental Health, Set\u00fabal Hospital Center, Rua Camilo Castelo Branco, 2910-446 Set\u00fabal, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anabela","family":"Valadas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Set\u00fabal Hospital Center, Rua Camilo Castelo Branco, 2910-446 Set\u00fabal, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Semedo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Set\u00fabal Hospital Center, Rua Camilo Castelo Branco, 2910-446 Set\u00fabal, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Jesus","sequence":"additional","affiliation":[{"name":"University Psychiatric Clinic, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25075"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3109\/09593985.2015.1110738"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.02.030"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.15040084"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00078"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12893"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0477-7"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.17.4.496"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2008.146"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-307343"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2016.14.3.302"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-017-0739-9"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-000-0030-6"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2009.05.013"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-170247"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0670-4"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-150160"}],"container-title":["Case Reports in Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crips\/2018\/3915657.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crips\/2018\/3915657.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crips\/2018\/3915657.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,18]],"date-time":"2018-02-18T18:31:25Z","timestamp":1518978685000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crips\/2018\/3915657\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":17,"alternative-id":["3915657","3915657"],"URL":"https:\/\/doi.org\/10.1155\/2018\/3915657","relation":{},"ISSN":["2090-682X","2090-6838"],"issn-type":[{"value":"2090-682X","type":"print"},{"value":"2090-6838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}