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The use of proteomic analysis to characterize whole saliva (WS) in SSc has gained an increasing attention in the last years and the identification of salivary proteins specific for SSc could lead to early diagnosis or new therapeutic targets. This review will present an overview about the use of WS in SSc studies. The proteomic technologies currently used for global identification of salivary proteins in SSc, as well as the advantages and limitations for the use of WS as a diagnostic tool, will be presented.<\/jats:p>","DOI":"10.1155\/2018\/3921247","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T19:31:21Z","timestamp":1520883081000},"page":"1-7","source":"Crossref","is-referenced-by-count":7,"title":["Salivary Biomarkers in Systemic Sclerosis Disease"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9121-7824","authenticated-orcid":true,"given":"Zeineb","family":"Zian","sequence":"first","affiliation":[{"name":"Biomedical Genomics and Oncogenetics Research Laboratory, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essa\u00e2di University, Tetouan, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaira","family":"Bakkach","sequence":"additional","affiliation":[{"name":"Biomedical 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