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We investigated the effects of lipoic acid, an antioxidant, on ROS production and aortic remodeling in a MFS mg\u0394<jats:sup>loxPneo<\/jats:sup> mouse model. MFS and WT (wild\u2010type) 1\u2010month\u2010old mice were allocated to 3 groups: untreated, treated with losartan, and treated with lipoic acid. At 6 months old, echocardiography, ROS production, and morphological analysis of aortas were performed. Aortic ROS generation in 6\u2010month\u2010old MFS animals was higher at advanced stages of disease in MFS. An unprecedented finding in MFS mice analyzed by OCT was the occurrence of focal inhomogeneous regions in the aortic arch, either collagen\u2010rich extremely thickened or collagen\u2010poor hypotrophic regions. MFS animals treated with lipoic acid showed markedly reduced ROS production and lower ERK1\/2 phosphorylation; meanwhile, aortic dilation and elastic fiber breakdown were unaltered. Of note, lipoic acid treatment associated with the absence of focal inhomogeneous regions in MFS animals. Losartan reduced aortic dilation and elastic fiber breakdown despite no change in ROS generation. In conclusion, oxidant generation by itself seems neutral with respect to aneurysm progression in MFS; however, lipoic acid\u2010mediated reduction of inhomogeneous regions may potentially associate with less anisotropy and reduced chance of dissection\/rupture.<\/jats:p>","DOI":"10.1155\/2018\/3967213","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T23:30:54Z","timestamp":1522020654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of the Antioxidant Lipoic Acid in Aortic Phenotype in a Marfan Syndrome Mouse Model"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5033-869X","authenticated-orcid":false,"given":"Maria C.","family":"Guido","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Debbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera M.","family":"Salemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine R.","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thayna","family":"Meirelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1003-2703","authenticated-orcid":false,"given":"Tha\u00eds L. 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