{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:54:55Z","timestamp":1769597695818,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ12H16015"],"award-info":[{"award-number":["LQ12H16015"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY13H160028"],"award-info":[{"award-number":["LY13H160028"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["2015KYA035"],"award-info":[{"award-number":["2015KYA035"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ12H16015"],"award-info":[{"award-number":["LQ12H16015"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY13H160028"],"award-info":[{"award-number":["LY13H160028"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["2015KYA035"],"award-info":[{"award-number":["2015KYA035"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Provincial Medicine and Health Science Fund","award":["LQ12H16015"],"award-info":[{"award-number":["LQ12H16015"]}]},{"name":"Zhejiang Provincial Medicine and Health Science Fund","award":["LY13H160028"],"award-info":[{"award-number":["LY13H160028"]}]},{"name":"Zhejiang Provincial Medicine and Health Science Fund","award":["2015KYA035"],"award-info":[{"award-number":["2015KYA035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,6,25]]},"abstract":"<jats:p>Ovarian cancer leads the worst prognosis among all types of gynecologic malignancies, and patients are often diagnosed at an advanced stage. Ovarian cancer also has a high rate of metastasis; however, the detailed mechanisms for ovarian cancer prone to metastasis remain unclear. In this study, we used continuous in vitro screening of the human ovarian cancer A2780 cell line to establish a cell line (A2780-M) which shows high invasiveness and motility. Compared to the parental cells, A2780-M cells express elevated protein levels of CD44, CD133, CD34, and<jats:italic>\u03b2<\/jats:italic>-catenin. A2780-M cells are also more resistant to chemotherapeutic agents SN-38 and Docetaxel. Thus, the A2780-M cell line is a new ovarian metastatic cancer cell line that expresses tumor stem cell surface markers and adhesion-related membrane proteins and is with higher motility and invasiveness.<\/jats:p>","DOI":"10.1155\/2018\/3972534","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T23:31:48Z","timestamp":1529969508000},"page":"1-9","source":"Crossref","is-referenced-by-count":8,"title":["Establishment and Characterization of a Highly Metastatic Ovarian Cancer Cell Line"],"prefix":"10.1155","volume":"2018","author":[{"given":"Jiang","family":"Ruibin","sequence":"first","affiliation":[{"name":"Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5882-0982","authenticated-orcid":true,"given":"Cheng","family":"Guoping","sequence":"additional","affiliation":[{"name":"Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology, Hangzhou, Zhejiang 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Zhiguo","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Maowei","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China"},{"name":"Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology, Hangzhou, Zhejiang 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan","family":"Danying","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9355-1703","authenticated-orcid":true,"given":"Feng","family":"Jianguo","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China"},{"name":"Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology, Hangzhou, Zhejiang 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-7986","authenticated-orcid":true,"given":"Gu","family":"Linhui","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China"},{"name":"Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology, Hangzhou, Zhejiang 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29227"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20113"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2003.13054.x"},{"issue":"3","key":"6","volume":"12","year":"2003","journal-title":"Prog Obstet Gynecol"},{"issue":"3","key":"7","first-page":"4","volume":"13","year":"1996","journal-title":"Laboratory Animal Science & Administration"},{"issue":"6","key":"8","volume":"27","year":"1998","journal-title":"Chinese Journal of Pathology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2010.12.010"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090300"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2610"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12226"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-013-0096-8"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00334-9"},{"issue":"4","key":"15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00432-003-0431-0","volume":"129","year":"2003","journal-title":"Journal of Cancer Research and Clinical Oncology"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v2.i8.311"},{"issue":"10","key":"17","first-page":"1838","volume":"58","year":"2017","journal-title":"The Japanese journal of clinical hematology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.11406\/rinketsu.56.1871"},{"issue":"23","key":"19","first-page":"3374","volume":"20","year":"2016","journal-title":"Chinese Journal of Tissue Engineering Research"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1630"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1102"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.04.001"},{"issue":"6","key":"23","first-page":"563","volume":"5","year":"2013","journal-title":"American Journal of Translational Research"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2013.01.003"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i31.10790"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15069422"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25967"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3175"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60101-3"},{"issue":"12","key":"30","first-page":"5059","volume":"7","year":"2014","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2015.2966"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11931"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/3972534.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/3972534.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/3972534.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T08:21:48Z","timestamp":1604478108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/3972534\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,25]]},"references-count":32,"alternative-id":["3972534","3972534"],"URL":"https:\/\/doi.org\/10.1155\/2018\/3972534","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,25]]}}}