{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:57:50Z","timestamp":1778774270758,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,8,19]],"date-time":"2018-08-19T00:00:00Z","timestamp":1534636800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,8,19]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. The management of bisphosphonate-related osteonecrosis of the jaw (BRONJ), with no evidence-based guidelines, remains controversial. We aimed to evaluate the efficiency of a conservative surgical treatment combining Er,Cr:YSGG laser and platelet-rich plasma (PRP) for the treatment of BRONJ in cancer patients.<jats:italic> Methods<\/jats:italic>. We performed a longitudinal cohort study. Inclusion criteria were (1) age \u2265 18 years; (2) cancer diagnosis; (3) treatment with NBP because of the underlying cancer.<jats:italic> Results<\/jats:italic>. We consecutively recruited ten patients diagnosed with BRONJ in stage I or II. These patients underwent a surgical laser-assisted therapy together with autologous PRP. At the latest follow-up at 12 months, clinical improvement was observed in eight patients. Registration Number is IRCT20180329039159N1.<jats:italic> Conclusion<\/jats:italic>. We could successfully manage the BRONJ utilizing this combined protocol to heal the 30% of surgically treated sites and to improve the 50% of patients\u2019 lesions clinically. Our findings suggest that a surgical approach combined with Er,Cr:YSGG laser and PRP benefit cancer patients with general health issues.<\/jats:p>","DOI":"10.1155\/2018\/3982540","type":"journal-article","created":{"date-parts":[[2018,8,19]],"date-time":"2018-08-19T19:31:05Z","timestamp":1534707065000},"page":"1-10","source":"Crossref","is-referenced-by-count":42,"title":["Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4008-6502","authenticated-orcid":true,"given":"Rodolfo","family":"Mauceri","sequence":"first","affiliation":[{"name":"Department of Surgical, Oncological and Oral Sciences, Sector of Oral Medicine \u201cV. 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