{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:26:22Z","timestamp":1791422782979,"version":"4.3.3"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,7,24]]},"abstract":"<jats:p>The therapeutic potential of stigmasterol, a natural steroid alcohol with established immune-modulatory properties, was assessed on allergic cutaneous responses. We examined its suppressive effect on immunoglobulin E (IgE)-mediated active cutaneous anaphylaxis (ACA), compound 48\/80 (C48\/80)-induced pruritus, and irritant dermatitis induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Stigmasterol at 10\u2013100\u2009mg\/kg significantly inhibited ACA with reduction in reaction area and concentration of the extravasated Evans blue dye. Given at 50 and 100\u2009mg\/kg, stigmasterol significantly inhibited C48\/80-induced scratching behaviour when compared to saline-treated C48\/80-injected control. Skin histopathology of injected sites confirmed that stigmasterol reduced mast cell trafficking and degranulation associated with C48\/80-induced pruritus. Stigmasterol controlled inflammatory features such as ear skin oedema and neutrophilia and also reduced serum levels of TNF<jats:italic>\u03b1<\/jats:italic> induced by topical application of TPA. Epidermal layer thickening and inflammatory cell infiltration of ear skin tissue were significantly reduced by stigmasterol. Taken together, stigmasterol demonstrates significant potential as a molecule of interest in allergic skin disease therapy.<\/jats:p>","DOI":"10.1155\/2018\/3984068","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T19:53:59Z","timestamp":1532462039000},"page":"1-13","source":"Crossref","is-referenced-by-count":41,"title":["Stigmasterol Alleviates Cutaneous Allergic Responses in Rodents"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-9487","authenticated-orcid":true,"given":"Aaron O.","family":"Antwi","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science & Technology (KNUST), Kumasi, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-9534","authenticated-orcid":true,"given":"David 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