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Baseline plasma cytokine levels and clinical data were analyzed in 125 women with FM and 130 age-matched healthy women. The FM women were then randomized to progressive resistance exercise (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>49<\/mml:mn><\/mml:math>) or relaxation (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>43<\/mml:mn><\/mml:math>). Baseline IL-2, IL-6, TNF-<jats:italic>\u03b1<\/jats:italic>, IP-10, and eotaxin were higher in FM than in healthy controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.041<\/mml:mn><\/mml:math>), whereas IL-1<jats:italic>\u03b2<\/jats:italic>was lower (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). There were weak correlations between cytokine levels and clinical variables. After both interventions, IL-1ra had increased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:math>), while IL-1<jats:italic>\u03b2<\/jats:italic>had increased in the relaxation group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>). Changes of IFN-<jats:italic>\u03b3<\/jats:italic>, IL-2, IL-4, IL-6, IL-8, and IL-17A were weakly correlated with changes of PPT, but there were no significant correlations between changes of cytokine and changes in other clinical variables. The elevated plasma levels of several cytokines supports the hypothesis that chronic systemic inflammation may underlie the pathophysiology of FM even if the relation to clinical variables was weak. However, 15 weeks of resistance exercise, as performed in this study, did not show any anti-inflammatory effect on neither FM symptoms nor clinical and functional variables. This trial is registered with<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/Clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/results?cond=&amp;term=NCT01226784&amp;cntry=&amp;state=&amp;city=&amp;dist=\">NCT01226784<\/jats:ext-link>, registered October 21, 2010. The first patient was recruited October 28, 2010.<\/jats:p>","DOI":"10.1155\/2018\/3985154","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T23:35:08Z","timestamp":1524094508000},"page":"1-14","source":"Crossref","is-referenced-by-count":70,"title":["Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4152-5439","authenticated-orcid":true,"given":"M.","family":"Ernberg","sequence":"first","affiliation":[{"name":"Department of Dental Medicine, Karolinska Institutet and Scandinavian Center for Orofacial Neurosciences (SCON), 141 04 Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Christidis","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Karolinska Institutet and Scandinavian Center for Orofacial Neurosciences 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