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On the one hand, H<jats:sub>2<\/jats:sub>S is produced from L\u2010cysteine by enzymes of cystathionine <jats:italic>\u03b3<\/jats:italic>\u2010lyase (CSE) and cystathionine <jats:italic>\u03b2<\/jats:italic>\u2010synthase (CBS), 3\u2010mercaptopyruvate sulfurtransferase (3MST) in combination with aspartate aminotransferase (AAT) (also called as cysteine aminotransferase, CAT); on the other hand, H<jats:sub>2<\/jats:sub>S is produced from D\u2010cysteine by enzymes of D\u2010amino acid oxidase (DAO). Besides sulfide salt, several sulfide\u2010releasing compounds have been synthesized, including organosulfur compounds, Lawesson\u2019s reagent and analogs, and plant\u2010derived natural products. Based on garlic extractions, we synthesized S\u2010propargyl\u2010L\u2010cysteine (SPRC) and its analogs to contribute our endeavors on drug development of sulfide\u2010containing compounds. A multitude of evidences has presented H<jats:sub>2<\/jats:sub>S is widely involved in the roles of physiological and pathological process, including hypertension, atherosclerosis, angiogenesis, and myocardial infarcts. This review summarizes current sulfide compounds, available H<jats:sub>2<\/jats:sub>S measurements, and potential molecular mechanisms involved in cardioprotections to help researchers develop further applications and therapeutically drugs.<\/jats:p>","DOI":"10.1155\/2018\/4010395","type":"journal-article","created":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T23:30:54Z","timestamp":1532907054000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["The Drug Developments of Hydrogen Sulfide on Cardiovascular 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