{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:37:39Z","timestamp":1792143459733,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2018,9,10]]},"abstract":"<jats:p>This work was designed to investigate the antibacterial activities of methanol extracts from thirteen Cameroonian edible plants and their antibiotic-potentiating effects against Gram-negative multidrug-resistant (MDR) phenotypes. The broth microdilution method was used to evaluate the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the extracts, as well as their antibiotic-potentiating activities. The phytochemical screening of the extracts was carried out according to the standard methods. The results of phytochemical tests revealed the presence of sterols, polyphenols, and tannins in most of the tested extracts, with the other classes of secondary metabolites being selectively distributed. Tested extracts showed variable antibacterial activities with MIC values ranging from 64 to 1024\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL. However, some extracts were significantly active against certain bacterial strains: seeds extract of<jats:italic> Theobroma cacao<\/jats:italic> (64\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) against<jats:italic> Escherichia coli<\/jats:italic> AG100Atet and<jats:italic> Klebsiella pneumoniae<\/jats:italic> K24, and the bark extract of<jats:italic> Uapaca guineensis <\/jats:italic>against<jats:italic> E. coli<\/jats:italic> ATCC 8739. The leaves extract of<jats:italic> T. cacao<\/jats:italic> displayed the best MBC values (256\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) against<jats:italic> E. aerogenes<\/jats:italic> EA27. Some tested extracts included extracts from the leaves of<jats:italic> T. cacao<\/jats:italic> and<jats:italic> P. vulgaris, <\/jats:italic>and the seeds of<jats:italic> D. edulis<\/jats:italic> and barks<jats:italic> A. indica<\/jats:italic> has selectively improved (2- to 64-fold) the antibacterial activities of some of the tested antibiotics, chloramphenicol (CHL), tetracycline (TET), kanamycin (KAN), streptomycin (STR), and erythromycin (ERY), against more than 70% of tested MDR bacteria. The findings of this work showed that tested plant extracts and particularly those from<jats:italic> T. cacao<\/jats:italic> and<jats:italic> Phaseolus vulgaris<\/jats:italic> can be used alone or in combination with conventional antibiotics in the treatment of infections involving multiresistant bacteria.<\/jats:p>","DOI":"10.1155\/2018\/4020294","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T19:30:39Z","timestamp":1536607839000},"page":"1-14","source":"Crossref","is-referenced-by-count":43,"title":["Antibacterial and Antibiotic-Potentiating Activities of Thirteen Cameroonian Edible Plants against Gram-Negative Resistant Phenotypes"],"prefix":"10.1155","volume":"2018","author":[{"given":"Paul","family":"Nayim","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4178-4967","authenticated-orcid":true,"given":"Armelle T.","family":"Mbaveng","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice E. N.","family":"Wamba","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aim\u00e9 G.","family":"Fankam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim K.","family":"Dzotam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1070-1236","authenticated-orcid":true,"given":"Victor","family":"Kuete","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Dschang, 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