{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T16:50:10Z","timestamp":1768409410504,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500466"],"award-info":[{"award-number":["81500466"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700502"],"award-info":[{"award-number":["81700502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670472"],"award-info":[{"award-number":["81670472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500466"],"award-info":[{"award-number":["81500466"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700502"],"award-info":[{"award-number":["81700502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670472"],"award-info":[{"award-number":["81670472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500466"],"award-info":[{"award-number":["81500466"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700502"],"award-info":[{"award-number":["81700502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670472"],"award-info":[{"award-number":["81670472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2018,12,4]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. Levo-tetrahydropalmatine (L-THP) is an active ingredient of <jats:italic>Corydalis yanhusuo<\/jats:italic> W. T. Wang, which has many bioactive properties. Herein, we investigated the protective effects of L-THP on concanavalin A- (ConA-) induced hepatitis in mice and explored its possible mechanisms of these effects. <jats:italic>Main Methods<\/jats:italic>. Balb\/c mice were intravenously injected with 25 mg\/kg ConA to generate a model of acute autoimmune hepatitis, and L-THP (20 or 40\u2009mg\/kg) was administered orally once daily for 5\u2009d before the ConA injection. The liver enzyme levels, proinflammatory cytokine levels, and other marker protein levels were determined 2, 8, and 24\u2009h after ConA injection. <jats:italic>Results<\/jats:italic>. L-THP could decrease serum liver enzymes and pathological damage by reducing the release of inflammatory factors like IL-6 and TNF-<jats:italic>\u03b1<\/jats:italic>. The results of Western Blot and PCR indicated that L-THP could ameliorate liver cell apoptosis and autophagy. L-THP could suppress T lymphocyte proliferation and the production of TNF-<jats:italic>\u03b1<\/jats:italic> and IL-6 induced by ConA in a dose-dependent manner <jats:italic>in vitro<\/jats:italic>. Additionally, the protective functions of L-THP depended on downregulating TRAF6\/JNK signaling<jats:italic>. Conclusion<\/jats:italic>. The present study indicated that L-THP attenuated acute liver injury in ConA-induced autoimmune hepatitis by inhibiting apoptosis and autophagy via the TRAF6\/JNK pathway.<\/jats:p>","DOI":"10.1155\/2018\/4032484","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T18:30:58Z","timestamp":1543948258000},"page":"1-15","source":"Crossref","is-referenced-by-count":24,"title":["The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6\/JNK Signaling"],"prefix":"10.1155","volume":"2018","author":[{"given":"Qiang","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai 200072, China"},{"name":"Shanghai Tenth Hospital, School of Clinical Medicine of Nanjing Medical University, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sainan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4429-9043","authenticated-orcid":true,"given":"Kan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9425-3612","authenticated-orcid":true,"given":"Yujing","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4140-4541","authenticated-orcid":true,"given":"Peiqin","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People's Hospital Chongming Branch, Tongji University School of Medicine, Shanghai 202157, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3438-8432","authenticated-orcid":true,"given":"Ling","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200336, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqi","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai 200032, China"},{"name":"Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8757-9657","authenticated-orcid":true,"given":"Yingqun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5658-600X","authenticated-orcid":true,"given":"Chuanyong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2017.07.002"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1159\/000440705"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.07.033"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S99420"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.03.012"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115836"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i2.119"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2748367"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.11.109"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S136792"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.12.1.198"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3273"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0321-5"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-007-9179-4"},{"issue":"8","key":"15","first-page":"715","volume":"20","year":"1999","journal-title":"Zhongguo Yao Li Xue Bao"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2010.11.023"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.01.028"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/752512"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038627"},{"issue":"6","key":"20","first-page":"483","volume":"31","year":"2006","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2017.1299173"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2018.06.055"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b17-00799"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.235259"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2011.08.003"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29140"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.8700"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.906153"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.04.016"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1007\/s40495-017-0117-y"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58818"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2017.4124"},{"issue":"5","key":"33","first-page":"1041","volume":"21","year":"2017","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29633"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101530"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24076-w"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00116-1"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120440"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/597512"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.09.027"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2016.108"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.109"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.4103\/jmp.JMP_104_17"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0438011100"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100279200"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.07.002"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2017.07.018"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.06.001"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.s98740"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S162950"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9724217"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3180396"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31022"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.323"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2018\/4032484.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2018\/4032484.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2018\/4032484.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T18:31:00Z","timestamp":1543948260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2018\/4032484\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,4]]},"references-count":54,"alternative-id":["4032484","4032484"],"URL":"https:\/\/doi.org\/10.1155\/2018\/4032484","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,4]]}}}