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Exercise benefits to cardiac rehabilitation (CR) following stable myocardial infarction (MI). The suitable exercise duration for aged patients with coronary heart disease (CHD) remains controversial, and the underlying molecular mechanism is still unclear. <jats:italic>Methods and Results<\/jats:italic>. 18\u2010Month\u2010old mice after stable MI were randomly submitted to different durations of exercise, including 15 and 60\u2009min swimming training (ST) once per day, five times a week for 8 weeks. Compared to sedentary mice, 15\u2009min ST, rather than 60\u2009min ST, significantly augmented left ventricular function, increased survival rate, and suppressed myocardial fibrosis and apoptosis. 15\u2009min ST improved mitochondrial morphology via regulating mitochondrial fission\u2010fusion signaling. 15\u2009min ST regulated mitophagy signaling via inhibiting LC3\u2010II and P62 levels and increasing PINK\/Parkin expression. 15\u2009min ST also inhibited ROS production and enhanced antioxidant SOD2 activity. Notably, 15\u2009min ST significantly increased sirtuin (SIRT) 3 level (2.7\u2010fold) in vivo while the inhibition of SIRT3 exacerbated senescent H9c2 cellular LDH release and ROS production under hypoxia. In addition, SIRT3 silencing impairs mitochondrial dynamics and mitophagy in senescent cardiomyocytes against simulated ischemia (SI) injury. <jats:italic>Conclusion<\/jats:italic>. Collectively, our study demonstrated for the first time that sustained short\u2010duration exercise, rather than long\u2010duration exercise, attenuates cardiac dysfunction after MI in aged mice. It is likely that the positive regulation induced by a short\u2010duration ST regimen on the elevated SIRT3 protein level improved mitochondrial quality control and decreased apoptosis and fibrosis contributed to the observed more resistant phenotype.<\/jats:p>","DOI":"10.1155\/2018\/4079041","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T23:31:00Z","timestamp":1523489460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Short\u2010Duration Swimming Exercise after Myocardial Infarction Attenuates Cardiac Dysfunction and Regulates Mitochondrial Quality Control in Aged 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