{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T14:28:40Z","timestamp":1747319320893,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Inflammation"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Introduction.<\/jats:italic> Acne vulgaris is a multifactorial disease. Recent study showed that inflammation does have a central role in the formation of both inflammatory and noninflammatory lesions in acne vulgaris. There are various findings of proinflammatory cytokines related to acne vulgaris, but no previous study correlate interleukin- (IL-) 19 to acne vulgaris. This pilot study aims to look at difference in IL-19 serum concentration on degrees of severity of acne vulgaris.<jats:italic> Methods.<\/jats:italic> This is an analytical observational cross-sectional study. Sample subjects were patients with acne vulgaris who met the inclusion criteria. Enzyme-linked immunosorbent assay (ELISA) study was applied to measure IL-19 serum.<jats:italic> Result.<\/jats:italic> Analysis test found statistically significant difference between IL-19 serum concentration of group of patients with mild acne vulgaris and that of group of patients with severe acne vulgaris. Moreover, analysis revealed significant difference between IL-19 serum concentration of group of patients with moderate acne vulgaris and that of group of patients with severe acne vulgaris.<jats:italic> Conclusions.<\/jats:italic> There are differences in serum levels of IL-19 on the severity of acne vulgaris. The significant difference might show that inflammation has a core role in severity of acne vulgaris, and IL-19 might potentially be related to acne vulgaris.<\/jats:p>","DOI":"10.1155\/2018\/4141579","type":"journal-article","created":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T19:32:26Z","timestamp":1522611146000},"page":"1-4","source":"Crossref","is-referenced-by-count":7,"title":["The Difference in Interleukin-19 Serum on Degrees of Acne Vulgaris Severity"],"prefix":"10.1155","volume":"2018","author":[{"given":"Moerbono","family":"Mochtar","sequence":"first","affiliation":[{"name":"Dermatovenerology Department, Sebelas Maret University, Dr. Moewardi General Hospital, Surakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7835-3461","authenticated-orcid":true,"given":"Alamanda","family":"Murasmita","sequence":"additional","affiliation":[{"name":"Dermatovenerology Department, Sebelas Maret University, Dr. Moewardi General Hospital, Surakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Eko","family":"Irawanto","sequence":"additional","affiliation":[{"name":"Dermatovenerology Department, Sebelas Maret University, Dr. Moewardi General Hospital, Surakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4246-4845","authenticated-orcid":true,"given":"Indah","family":"Julianto","sequence":"additional","affiliation":[{"name":"Dermatovenerology Department, Sebelas Maret University, Dr. Moewardi General Hospital, Surakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harijono","family":"Kariosentono","sequence":"additional","affiliation":[{"name":"Dermatovenerology Department, Sebelas Maret University, Dr. Moewardi General Hospital, Surakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fajar","family":"Waskito","sequence":"additional","affiliation":[{"name":"Dermatovenerology Department, Gadjah Mada University, Dr. Sardjito\u2019 General Hospital, Yogyakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-014-1519-x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10949.x"},{"key":"3","first-page":"27","volume":"6","year":"2013","journal-title":"The Journal of Clinical Aesthet Dermatol"},{"key":"4","first-page":"22","volume":"8","year":"2013","journal-title":"Practical Dermatology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.07.015"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-014-0099-z"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker174"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425317"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06800.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2006.00516.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12339"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.11.6712"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2010.08.005"},{"year":"2013","key":"14"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.5935\/scd1984-8773.2015731682"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.505"},{"journal-title":"Clinical and Experimental Immunology","first-page":"64","year":"2014","key":"17"},{"key":"18","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nri3766","volume":"14","year":"2014","journal-title":"Nature Review Immunology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06665.x"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0488-7"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.15395\/mkb.v48n3.846"},{"issue":"6","key":"22","first-page":"406","volume":"33","year":"2008","journal-title":"Zhen Ci Yan Jiu"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/63.8.879"},{"volume-title":"The role of Interleukin-19 in Interleukin-10 production by regulatory macrophages","year":"2010","key":"24"}],"container-title":["International Journal of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/iji\/2018\/4141579.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/iji\/2018\/4141579.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/iji\/2018\/4141579.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T19:32:28Z","timestamp":1522611148000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/iji\/2018\/4141579\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":24,"alternative-id":["4141579","4141579"],"URL":"https:\/\/doi.org\/10.1155\/2018\/4141579","relation":{},"ISSN":["2090-8040","2042-0099"],"issn-type":[{"type":"print","value":"2090-8040"},{"type":"electronic","value":"2042-0099"}],"subject":[],"published":{"date-parts":[[2018]]}}}