{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:32:39Z","timestamp":1772821959576,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T00:00:00Z","timestamp":1542758400000},"content-version":"vor","delay-in-days":324,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773859"],"award-info":[{"award-number":["81773859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Pinosylvin is a potential anti\u2010inflammatory and antioxidant compound and the major effective medicinal ingredient in the root of <jats:italic>Lindera reflexa<\/jats:italic> Hemsl. However, few investigations have been conducted regarding the pharmacokinetics, excretion, characteristics of tissue distribution, and major metabolites of pinosylvin in rats after oral administration. To better understand the behavior and mechanisms of action underlying the activity of pinosylvin <jats:italic>in vivo<\/jats:italic>, we established a simple, sensitive, and reliable ultra\u2010high\u2010performance liquid chromatography tandem mass spectrometry (UPLC\u2010MS\/MS) method for quantifying pinosylvin in rat plasma, urine, feces, and various tissues (including heart, liver, spleen, lung, kidneys, large intestine, small intestine, and stomach). Noncompartmental pharmacokinetic parameters indicated that pinosylvin is rapidly distributed and taken up by tissues. The time to peak (maximum) concentration (T<jats:sub>max<\/jats:sub>) was 0.137 h, and the apparent elimination half\u2010life (t<jats:sub>1\/2<\/jats:sub>) was 1.347\u00b10.01 h. The results of the tissue distribution study suggest that pinosylvin is widely distributed to various tissues; the highest concentration was observed after 10 min in the stomach, followed by the heart, lung, spleen, and kidneys. Results of the excretion study suggest that a small amount of pinosylvin is excreted from the urine and feces in the parent form; the 73 h accumulative excretion ratios of urine and feces were 0.82% and 0.11%, respectively. It is likely that pinosylvin is mostly metabolized <jats:italic>in vivo<\/jats:italic>. Nine metabolites were found, and the main metabolic pathways of pinosylvin in rats included glucuronidation, hydroxylation, and methylation. Four metabolites had higher concentrations in the stomach, suggesting that the stomach is a potential target organ of pinosylvin. In conclusion, the present study may provide a material basis for studying the pharmacological action of pinosylvin and provides meaningful information for the clinical treatment of chronic gastritis and gastric ulcers using Radix Linderae Reflexae.<\/jats:p>","DOI":"10.1155\/2018\/4181084","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T23:30:59Z","timestamp":1542843059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pharmacokinetics and Tissue Distribution Study of Pinosylvin in Rats by Ultra\u2010High\u2010Performance Liquid Chromatography Coupled with Linear Trap Quadrupole Orbitrap Mass Spectrometry"],"prefix":"10.1155","volume":"2018","author":[{"given":"Yuhang","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoya","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0449-168X","authenticated-orcid":false,"given":"Suiqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,21]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201500454"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00776646"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2015.07.005"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.4268\/cjcmm20130715"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00040665"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.09.022"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4770"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2011.04.021"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2013.05.023"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.10.005"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2416"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2014-0271"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01946707"},{"key":"e_1_2_9_14_2","unstructured":"Jiangsu New Medical College Dictionary of Chinese Medicine 1975 Shanghai Scientific & Technical Publishers Shanghai China."},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/10826076.2016.1169429"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2016.04.023"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2004.12.015"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.58.11.0004"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2014.04.038"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2014.08.003"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2014.08.031"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.05.042"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201700166"},{"key":"e_1_2_9_24_2","first-page":"75","article-title":"Establish the quantitative model of 3, 5-didroxystilbene in Lindera reflexa Hemsl by near-infrared spectroscopy","volume":"17","author":"Lei J. 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