{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:12:41Z","timestamp":1759565561952,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,22]],"date-time":"2018-07-22T00:00:00Z","timestamp":1532217600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2018,7,22]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To investigate the effectiveness of mineralocorticoid receptor (MR) antagonist in patients with steroid-induced central serous chorioretinopathy (CSC). <jats:italic>Methods<\/jats:italic>. A retrospective review was conducted of steroid-induced CSC patients who were treated with the MR antagonist spironolactone 50\u2009mg once per day for at least 1 month. The primary outcome measure was complete resolution rate of subretinal fluid (SRF) after spironolactone treatment. Secondary outcomes included central subfield thickness (CST), subfoveal choroidal thickness (SFCT), and best-corrected visual acuity (BCVA) changes after spironolactone treatment. <jats:italic>Results<\/jats:italic>. Seventeen eyes from 15 patients were included in this study. Conditions warranting chronic systemic steroid use were myasthenia gravis (6\/15, 40%), glomerulonephritis (5\/15, 33.3%), and organ transplantation (4\/15, 26.7%). Mean symptom duration of CSC was 4.00\u2009\u00b1\u20093.04 months. After spironolactone treatment, 14 eyes (82.4%) showed complete resolution of SRF (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>) without discontinuation of systemic steroid. CST and BCVA were significantly improved after spironolactone treatment. SFCT was significantly decreased after spironolactone treatment. No patients experienced electrolyte imbalance after spironolactone treatment. <jats:italic>Conclusion<\/jats:italic>. MR antagonist treatment may be a therapeutic option for steroid-induced CSC patients. This treatment modality may be especially beneficial for steroid-induced CSC patients who cannot discontinue steroid medication due to systemic conditions.<\/jats:p>","DOI":"10.1155\/2018\/4258763","type":"journal-article","created":{"date-parts":[[2018,7,22]],"date-time":"2018-07-22T19:31:06Z","timestamp":1532287866000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["Mineralocorticoid Receptor Antagonist Treatment for Steroid-Induced Central Serous Chorioretinopathy Patients with Continuous Systemic Steroid Treatment"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6204-9537","authenticated-orcid":true,"given":"Jin Young","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5233-0373","authenticated-orcid":true,"given":"Ju Byung","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5307-4597","authenticated-orcid":true,"given":"Jisoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6058-0145","authenticated-orcid":true,"given":"Dong Yoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chungbuk National 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