{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:21:39Z","timestamp":1762507299652,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2014HP058","2014-032"],"award-info":[{"award-number":["ZR2014HP058","2014-032"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010848","name":"Health and Family Planning Commission of Shandong Province","doi-asserted-by":"crossref","award":["ZR2014HP058","2014-032"],"award-info":[{"award-number":["ZR2014HP058","2014-032"]}],"id":[{"id":"10.13039\/501100010848","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS).<jats:italic>Methods<\/jats:italic>. A cross-sectional study of 91 Chinese children and adolescents with ISS was performed. Anthropometric measurements and biochemical parameters were tested. The standard deviation score of IGF-1 (IGF-1 SDS) was calculated.<jats:italic>Results<\/jats:italic>. A univariate analysis displayed a significant positive correlation between IGF-1 SDS and UA (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.004<\/mml:mn><\/mml:math>). In multivariate piecewise linear regression, the levels of IGF-1 SDS increased with the elevation of UA when UA was between 168\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L and 301\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L (<jats:italic>\u03b2<\/jats:italic>0.010, 95% CI 0.004\u20130.017;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.002<\/mml:mn><\/mml:math>). The levels of IGF-1 SDS decreased with the elevation of UA when UA was either less than 168\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L (<jats:italic>\u03b2<\/jats:italic>\u2009\u2009\u22120.055, 95% CI \u22120.081\u2013\u22120.028;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) or more than 301\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L (<jats:italic>\u03b2<\/jats:italic>\u2009\u2009\u22120.005, 95% CI \u22120.013\u20130.002;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.174<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. This study demonstrated a nonlinear relationship between IGF-1 and UA levels in Chinese children and adolescents with ISS. This finding suggests that either high or low levels of UA may have an adverse effect on IGF-1, whereas appropriate UA levels have a beneficial effect.<\/jats:p>","DOI":"10.1155\/2018\/4259098","type":"journal-article","created":{"date-parts":[[2018,1,28]],"date-time":"2018-01-28T23:31:22Z","timestamp":1517182282000},"page":"1-6","source":"Crossref","is-referenced-by-count":8,"title":["Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0218-6019","authenticated-orcid":true,"given":"Panpan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, 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