{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:38:49Z","timestamp":1777549129237,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2018CFB455"],"award-info":[{"award-number":["2018CFB455"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,11,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Very few studies have been conducted to compare carbon dioxide laser microsurgery (CO2-LS) with low-temperature plasma radiofrequency ablation (LTP-RFA) in treating T1a glottic cancer. Therefore, we conducted this study to compare the efficacy of CO2-LS and LTP-RFA to define a superior therapeutic modality for T1a glottic cancer.<jats:italic>Methods<\/jats:italic>. Patients (n=131) with T1a glottic cancer were recruited between January 2010 and September 2014. The included patients were randomly assigned to either receive CO2-LS (n=65) or LTP-RFA (n=66). We conducted the following multidimensional vocal assessments: (i) videostroboscopic evaluation; (ii) auditory-perceptual evaluation; (iii) aerodynamics\/ efficiency; (iv) acoustics; and (v) self-assessment questionnaires. Meanwhile, the surgery time and three-year overall survival rates in two groups were recorded. The predefined primary endpoint was overall survival, and the minimum follow-up time was set to six months.<jats:italic>Results<\/jats:italic>. After treatment, we found that the structure and vibration of vocal cord might recover more quickly in patients receiving LTP-RFA than in patients receiving CO2-LS, and moreover, the patients in the LTP-RFA group had the better vocal functions. Meanwhile, the surgery time was significantly less in the LTP-RFA group (8.83\u00b11.59 minutes) than in the CO2-LS group (12.49\u00b11.40 minutes) (p&lt;0.00001). In addition, the two intervention methods had the similar three-year overall survival rates (94% versus 96%, p=0.58).<jats:italic>Conclusion<\/jats:italic>. These results indicated that both LTP-RFA and CO2-LS could effectively treat T1a glottic cancer, and LTP-RFA might have some advantages in voice function. Limited by the relatively small sample size, future studies were needed to validate our conclusion.<\/jats:p>","DOI":"10.1155\/2018\/4295960","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T23:51:30Z","timestamp":1541116290000},"page":"1-9","source":"Crossref","is-referenced-by-count":17,"title":["Carbon Dioxide Laser Microsurgery versus Low-Temperature Plasma Radiofrequency Ablation for T1a Glottic Cancer: A Single-Blind Randomized Clinical Trial"],"prefix":"10.1155","volume":"2018","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The Third Hospital of Wuhan City, Wuhan, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binru","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Third Hospital of Wuhan City, Wuhan, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangbin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Third Hospital of Wuhan City, Wuhan, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9468-9934","authenticated-orcid":true,"given":"Gengtian","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Third Hospital of Wuhan City, Wuhan, Hubei Province, 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