{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T10:42:24Z","timestamp":1764240144245,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hepatology"],"published-print":{"date-parts":[[2018,5,31]]},"abstract":"<jats:p>Hereditary hemochromatosis (HH) is a genetic disease associated with progressive iron overload, eventually leading in some cases to damage of parenchymal organs, such as the liver, pancreas, and heart. Although the gene had been identified (HFE), HH pathogenesis remains to be fully elucidated. We report here, for the first time, a case of inadvertent transplantation of a liver from a donor with C282Y\/H63D compound heterozygosity into a nonhemochromatotic 19-year-old Caucasian male recipient with primary sclerosing cholangitis. Progressive iron overload occurred over 1.5 years, as observed in liver biopsies and iron studies, after ruling out secondary causes of iron overload. This case strengthens the hypothesis that the liver, rather than the small intestine, plays a primary role in the maintenance of iron homeostasis.<\/jats:p>","DOI":"10.1155\/2018\/4298649","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T19:36:07Z","timestamp":1527795367000},"page":"1-4","source":"Crossref","is-referenced-by-count":3,"title":["Hepatic Iron Overload following Liver Transplantation from a C282Y\/H63D Compound Heterozygous Donor"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2296-7058","authenticated-orcid":true,"given":"E.","family":"Veitsman","sequence":"first","affiliation":[{"name":"Liver Disease Center, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Pras","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Sheba Medical Center, Ramat Gan, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Pappo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Arish","sequence":"additional","affiliation":[{"name":"Hepato-Biliary-Pancreatic Surgery Department, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Eshkenazi","sequence":"additional","affiliation":[{"name":"Hepato-Biliary-Pancreatic Surgery Department, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Feray","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Henri Mondor Hospital, Cr\u00e9teil, France"},{"name":"Unite Inserm 955, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Calderaro","sequence":"additional","affiliation":[{"name":"Unite Inserm 955, France"},{"name":"Department of Pathology, Henri Mondor Hospital, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Azoulay","sequence":"additional","affiliation":[{"name":"Unite Inserm 955, France"},{"name":"Department Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Henri Mondor Hospital, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z. 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