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In order to restore loss of function of resident or transplanted CPCs, much research has focused on novel therapeutic strategies including the discovery of novel function\u2010modulating factors such as reactive oxygen species (ROS) scavengers. Here, we developed and defined a novel antioxidant, MHY\u20101684, for enhancing the angiogenic potential of CPCs against ROS\u2010related DCM. Short\u2010term treatment with MHY\u20101684 restored ROS\u2010induced CPC cell death. Importantly, MHY\u20101684 decreased hyperglycemia\u2010induced mitochondrial ROS generation and attenuated hyperglycemia\u2010induced mitochondrial fragmentation. We observed that the activation process of both Drp1 (phosphorylation at the site of Ser616) and Fis\u20101 is drastically attenuated when exposed to high concentrations of D\u2010glucose with MHY\u20101684. Interestingly, phosphorylation of Drp1 at the site of Ser637, which is an inhibitory signal for mitochondrial fusion, is restored by MHY\u20101684 treatment, suggesting that this antioxidant may affect the activation and inhibition of mitochondrial dynamics\u2010related signaling and mitochondrial function in response to ROS stress. In conclusion, our finding of the novel compound, MHY\u20101684, as an ROS scavenger, might provide an effective therapeutic strategy for CPC\u2010based therapy against diabetic cardiomyopathy.<\/jats:p>","DOI":"10.1155\/2018\/4528184","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T23:30:49Z","timestamp":1527723049000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cytoprotective Roles of a Novel Compound, MHY\u20101684, against Hyperglycemia\u2010Induced Oxidative Stress and Mitochondrial Dysfunction in Human Cardiac Progenitor Cells"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4919-2202","authenticated-orcid":false,"given":"Woong Bi","family":"Jang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji 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