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Although the majority of individuals infected with<jats:italic>E. histolytica<\/jats:italic>remain asymptomatic, some present with amoebic colitis and disseminated disease. As more is learned about its pathogenesis and the host\u2019s immune response, the potential for developing a vaccine holds promise. This narrative review outlines the current knowledge regarding<jats:italic>E. histolytica<\/jats:italic>and<jats:italic>E. dispar<\/jats:italic>and insight in the development of a vaccine.<\/jats:p>","DOI":"10.1155\/2018\/4601420","type":"journal-article","created":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T18:32:43Z","timestamp":1543775563000},"page":"1-6","source":"Crossref","is-referenced-by-count":168,"title":["Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6697-7218","authenticated-orcid":true,"given":"Micaella","family":"Kantor","sequence":"first","affiliation":[{"name":"Kendall Regional Medical Center, Miami, FL, 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