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However, no studies examined involvement of H<jats:sub>2<\/jats:sub>S in Pb-induced hypertension. We found increases in diastolic blood pressure and mean blood pressure in Pb-intoxicated humans followed by diminished H<jats:sub>2<\/jats:sub>S plasmatic levels. In order to expand our findings, male Wistar rats were divided into four groups: Saline, Pb, NaHS, and Pb + NaHS. Pb-intoxicated animals received intraperitoneally (i.p.) 1st dose of 8\u2009<jats:italic>\u03bc<\/jats:italic>g\/100\u2009g of Pb acetate and subsequent doses of 0.1\u2009<jats:italic>\u03bc<\/jats:italic>g\/100\u2009g for seven days and sodium hydrosulfide- (NaHS-) treated animals received i.p. NaHS injections (50\u2009<jats:italic>\u03bc<\/jats:italic>mol\/kg\/twice daily) for seven days. NaHS treatment blunted increases in systolic blood pressure, increased H<jats:sub>2<\/jats:sub>S plasmatic levels, and diminished whole-blood lead levels. Treatment with NaHS in Pb-induced hypertension seems to induce a protective role in rat aorta which is dependent on endothelium and seems to promote non-NO-mediated relaxation. Pb-intoxication increased oxidative stress in rats, while treatment with NaHS blunted increases in plasmatic MDA levels and increased antioxidant status of plasma. Therefore, H<jats:sub>2<\/jats:sub>S pathway may be involved in Pb-induced hypertension and treatment with NaHS exerts antihypertensive effect, promotes non-NO-mediated relaxation, and decreases oxidative stress in rats with Pb-induced hypertension.<\/jats:p>","DOI":"10.1155\/2018\/4627391","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T19:30:51Z","timestamp":1522351851000},"page":"1-13","source":"Crossref","is-referenced-by-count":15,"title":["Clinical and Experimental Evidences of Hydrogen Sulfide Involvement in Lead-Induced Hypertension"],"prefix":"10.1155","volume":"2018","author":[{"given":"Jos\u00e9 S\u00e9rgio","family":"Possomato-Vieira","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5194-0073","authenticated-orcid":true,"given":"Victor 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